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Merck

32301

Ammonium acetate

puriss. p.a., ACS reagent, reag. Ph. Eur., ≥98%

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About This Item

Linear Formula:
CH3CO2NH4
CAS Number:
Molecular Weight:
77.08
NACRES:
NA.21
PubChem Substance ID:
eCl@ss:
39021908
UNSPSC Code:
12352300
EC Number:
211-162-9
MDL number:
Beilstein/REAXYS Number:
4186741
assay:
≥98%
form:
solid

Product Name

Ammonium acetate, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥98%

InChI key

USFZMSVCRYTOJT-UHFFFAOYSA-N

InChI

1S/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3

SMILES string

N.CC(O)=O

grade

ACS reagent
puriss. p.a.

agency

reag. Ph. Eur.

vapor pressure

<0.001 hPa

assay

≥98%

form

solid

impurities

≤0.005% KMnO4 red. matter (as O)
≤2% water (Karl Fischer)
≤5 mg/kg heavy metals (as Pb)

ign. residue

≤0.01%

pH

6.7-7.3 (25 °C, 5% in water)

mp

110-112 °C (dec.) (lit.)

anion traces

chloride (Cl-): ≤5 mg/kg
nitrate (NO3-): ≤10 mg/kg
sulfate (SO42-): ≤10 mg/kg

cation traces

Ca: ≤10 ppm
Cd: ≤2 ppm
Co: ≤5 ppm
Cr: ≤5 ppm
Cu: ≤2 ppm
Fe: ≤5 ppm
K: ≤50 ppm
Mg: ≤2 ppm
Mn: ≤5 ppm
Na: ≤50 ppm
Ni: ≤5 ppm
Pb: ≤2 ppm
Zn: ≤2 ppm

Quality Level

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Application

Ammonium acetate has been used in the mobile phase for the HPLC determination of ezetimibe and its metabolites. It may be used in preparation of phenanthrimidazoles and retinimidazoles.

General description

Ammonium acetate is a colorless hygroscopic solid. It can be prepared by reacting glacial acetic acid with ammonia or ammonium carbonate. It has been reported as potential inhibitor of Pd/C mediated hydrogenolysis of benzyl ether.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Anima Ghosal et al.
Drug metabolism and disposition: the biological fate of chemicals, 32(3), 314-320 (2004-02-24)
Ezetimibe [1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone] (Zetia; Schering-Plough, Kenilworth, NJ) is the first in a new class of cholesterol-lowering agents known as cholesterol absorption inhibitors. The objective of this study was to identify the isoform(s) of human liver and intestinal UDP-glucuronosyltransferase (UGT) enzymes responsible
Reactions of phenanthraquinone and retenequinone with aldehydes and ammonium acetate in acetic acid solution1.
Steck EA and Day AR.
Journal of the American Chemical Society, 65(3), 452-456 (1943)
Selective inhibition of benzyl ether hydrogenolysis with Pd/C due to the presence of ammonia, pyridine or ammonium acetate.
Sajiki H.
Tetrahedron Letters, 36(20), 3465-3468 (1995)
M Athar Masood et al.
Basic & clinical pharmacology & toxicology, 127(6), 533-550 (2020-11-03)
Urine drug testing (UDT) is an important analytical/bio-analytical technique that has inevitably become an integral and vital part of a testing programme for diagnostic purposes. This manuscript presents a tailor-made LC-MS/MS quantitative assay method development and validation for a custom

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