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Merck

C1240

Chlormethiazole hydrochloride

≥98% (HPLC), GABAA agonist, powder

Synonym(s):

4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H8ClNS · HCl
CAS Number:
6001-74-7
Molecular Weight:
198.11
UNSPSC Code:
12352200
PubChem Substance ID:
329774745
NACRES:
NA.77
MDL number:
MFCD00673948
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

Chlormethiazole hydrochloride, ≥98% (HPLC), powder

SMILES string

Cl.Cc1ncsc1CCCl

InChI

1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H

InChI key

OFXYKSLKNMTBHK-UHFFFAOYSA-N

description

Store desiccated

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

H2O: soluble >10 mg/mL

originator

AstraZeneca

Quality Level

100

Related Categories

Biochem/physiol Actions

Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.
GABAA agonist; glycine receptor modulator.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000511920
0000511920
0000224447
0000222297
0000222296

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Rachael M Nelson et al.
European journal of pharmacology, 452(3), 255-262 (2002-10-03)
Clomethiazole is a gamma-aminobutyric acid (GABA)-mimetic agent with anticonvulsant, sedative and neuroprotective properties. The pharmacological actions of clomethiazole that underlie its functional profile have not been fully explored, but are known to result from an interaction with the GABA(A) receptor.
M Gasior et al.
The Journal of pharmacology and experimental therapeutics, 295(1), 153-161 (2000-09-19)
Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several experimental and clinical studies reporting effectiveness against the toxic effects
Koichi Nisijima et al.
Neurochemistry international, 43(2), 155-164 (2003-03-07)
The serotonin (5-HT) syndrome is the most serious toxic interaction of antidepressants, but no pharmacotherapy has yet been established. In the present study, we created an animal model of the 5-HT syndrome by intraperitoneally injecting rats with clorgyline (2 mg/kg)
A Nurse's Survival Guide to Acute Medical Emergencies (2011)
Pediatric Critical Care Medicine: Basic Science And Clinical Evidence, 985-985 (2007)
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