P2499
PD 173074
≥96% (HPLC), FGFR1 and receptor-3 inhibitor, powder
Synonym(s):
N-[2-[[4-(Diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea
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About This Item
Product Name
PD 173074, ≥96% (HPLC), powder
Quality Level
assay
≥96% (HPLC)
form
powder
color
faintly yellow to dark yellow
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c3cc(OC)cc(OC)c3
InChI
1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
InChI key
DXCUKNQANPLTEJ-UHFFFAOYSA-N
Gene Information
human ... FGFR1(2260), KDR(3791)
mouse ... Pdgfrb(18596)
Application
- to treat epithelial-mesenchymal transition (EMT)-induced cell lines in order to study its therapeutic use for head and neck squamous cell carcinoma (HNSCC)
- in combination with PD0325901 to test whether an alternative downstream pathway for (fibroblast growth factor) FGF signalling is adopted during human hypoblast induction
- to study its potential role in acute lymphoblastic leukaemia (ALL)-derived cell lines (TOM-1 and NALM-20)
Biochem/physiol Actions
Features and Benefits
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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