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Merck

S7947

Stattic

≥98% (HPLC), STAT3 activation inhibitor, powder

Synonym(s):

6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

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About This Item

Empirical Formula (Hill Notation):
C8H5NO4S
CAS Number:
19983-44-9
Molecular Weight:
211.19
UNSPSC Code:
12352200
PubChem Substance ID:
329824592
NACRES:
NA.77
MDL number:
MFCD00173799

Key Documents

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Product Name

Stattic, ≥98% (HPLC), powder

SMILES string

[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1

InChI key

ZRRGOUHITGRLBA-UHFFFAOYSA-N

InChI

1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >20 mg/mL

Quality Level

100

Related Categories

Application

Stattic has been used to inhibit signal transducer and activator of transcription 3 (STAT3) activity in various cell lines and culture.
Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.5

Biochem/physiol Actions

Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.2 Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,3 and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.4
Stattic is an irreversible STAT3 activation inhibitor.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000481122
0000464130
0000464130
0000338671
0000405974

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Yunbao Pan et al.
PloS one, 8(1), e54565-e54565 (2013-02-06)
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy most common in East Asia, Africa and Alaska. Radiotherapy and cisplatin-based chemotherapy are the main treatment options. Unfortunately, disease response to concurrent chemoradiotherapy varies among patients with NPC, and many cases are
Nikolaos Sismanopoulos et al.
PloS one, 7(3), e33271-e33271 (2012-03-14)
Interleukin 9 (IL-9) has been implicated in mast cell-related inflammatory diseases, such as asthma, where vascular endothelial growth factor (VEGF) is involved. Here we report that IL-9 (10-20 ng/ml) induces gene expression and secretion of VEGF from human LAD2. IL-9
Jochen Schust et al.
Chemistry & biology, 13(11), 1235-1242 (2006-11-23)
Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that transmit signals from the cell membrane to the nucleus. One family member, STAT3, is constitutively activated by aberrant upstream tyrosine kinase activities in a
Proatherogenic stimuli induce HuR in atherosclerosis through MAPK/ErK pathway
Cheng M, et al.
American Journal of Translational Research, 11(4), 2317-2317 (2019)
Karen Kwofie et al.
Respiratory research, 16, 14-14 (2015-04-08)
Regulation of human airway smooth muscle cells (HASMC) by cytokines contributes to chemotactic factor levels and thus to inflammatory cell accumulation in lung diseases. Cytokines such as the gp130 family member Oncostatin M (OSM) can act synergistically with Th2 cytokines
View All Related Papers

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