SML0087
MEGX
≥95% (HPLC)
Synonym(s):
MGEX, Monoethylglycinexylidide, N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide, Norlidocaine
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About This Item
Empirical Formula (Hill Notation):
C12H18N2O
CAS Number:
Molecular Weight:
206.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC1=C(NC(CNCC)=O)C(C)=CC=C1
InChI
1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15)
InChI key
WRMRXPASUROZGT-UHFFFAOYSA-N
Application
MEGX has been used in an approach to improve the yield of N-dealkylated lidocaine.
Biochem/physiol Actions
Lidocaine metabolite
Monoethylglycinexylidide (MEGX) is an active metabolite of lidocaine.
MEGX is generated by hepatic cytochrome P-450 system upon oxidative de-ethylation. Measurement of MEGX by immunoassay contributes to liver function test. MEGX possesses antiarrhythmic action and therefore extends lidocaine effect.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dinakaran Venkatachalam et al.
Animals : an open access journal from MDPI, 8(8) (2018-08-22)
This study determined the convulsant plasma concentrations and pharmacokinetic parameters following cornual nerve block and compared the results to recommend a safe dose of lidocaine hydrochloride for goat kids. The plasma concentrations of lidocaine and monoethylglycinexylidide (MGX) were quantified using
Georgette Oni et al.
Aesthetic surgery journal, 30(6), 853-858 (2010-12-07)
Topical lidocaine is a common form of anesthesia for a wealth of procedures across a large number of disciplines, including laser treatments. Preparations can be purchased over the counter with no prescription necessary. It is considered a safer and more
Hamdah M Al Nebaihi et al.
Journal of pharmaceutical sciences, 109(2), 1199-1210 (2019-11-17)
The effects of a high-fat diet on mRNA and protein of cytochrome P450 (CYP) enzymes in rats and mice and its impact on lidocaine deethylation to its main active metabolite, monoethylglycinexylidide (MEGX), in rats were investigated. The effect of a