191884
Hydroxypropyl cellulose
average Mw ~100,000, powder, 20 mesh particle size (99% through)
Synonym(s):
Cellulose & cellulose derivatives
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About This Item
description
biological oxygen demand (BOD) 14,000 ppm
Quality Level
form
powder
autoignition temp.
752 °F
mol wt
average Mw ~100,000
impurities
<5 wt. %
particle size
20 mesh (99% through)
pH
5.0-8.5
interfacial tension mineral oil
12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)
viscosity
65-175 cP, 5 wt. % in H2O(25 °C, Brookfield, spindle #1) (30 rpm)(lit.)
solubility
polar organic solvents: soluble
density
0.5 g/mL at 25 °C (lit.)
SMILES string
N(C)(C)c1cc(c(cc1)C(N)CC)C
InChI
1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3
InChI key
RRHXDYJWVYFMKV-UHFFFAOYSA-N
General description
Hydroxypropyl cellulose (HPC) is a neutral polysaccharide prepared by reacting propylene oxide with alkali cellulose at high temperatures and pressure. It is soluble in water and many polar organic solvents. HPC is widely used as a food additive and in drug delivery systems.
Application
Hydroxypropyl cellulose can be used in the following applications:
- HPC is soluble in organic solvents which makes it suitable for the preparation of polymer gel electrolytes for electrochemical devices. The network-forming ability of HPC can improve the mechanical and electrical properties of gel electrolytes.
- Electrospun hydroxypropyl cellulose nanofibres can be used to develop drug delivery systems for a variety of hydrophobic drugs.
- Hydroxypropylcellulose combined with an effervescent agent like sodium carbonate can be usedas a binder and functional material to prepare floating tablets for thecontrolled release of ofloxacin.
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Jeremiah F Kelleher et al.
AAPS PharmSciTech, 21(1), 23-23 (2019-12-14)
The development of oral solid dosage forms, such as tablets that contain a high dose of drug(s), requires polymers and other additives to be incorporated at low levels as possible, to keep the final tablet weight low, and, correspondingly, the
Xiaole Qi et al.
International journal of pharmaceutics, 489(1-2), 210-217 (2015-05-10)
To prolong the residence time of dosage forms within gastrointestinal trace until all drug released at desired rate was one of the real challenges for oral controlled-release drug delivery system. Herein, we developed a fine floating tablet via compression coating
Weibin Deng et al.
Drug development and industrial pharmacy, 39(2), 290-298 (2012-04-25)
The objective of this study was to improve the dissolution rate and to enhance the stability of a poorly water-soluble and low glass-trasition temperature (T(g)) model drug, fenofibrate, in low molecular weight grades of hydroxypropylcellulose matrices produced by hot-melt extrusion