Skip to Content
Merck

Key Documents

View All Documentation

22600

Quinidine

crystallized, ≥98.0% (dried material, NT)

Synonym(s):

β-Quinidine, (+)-Quinidine, (9S)-6′-Methoxycinchonan-9-ol, Chinidin

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C20H24N2O2
CAS Number:
56-54-2
Molecular Weight:
324.42
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
57647992
EC Number:
200-279-0
Beilstein/REAXYS Number:
91866
MDL number:
MFCD00135581
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥98.0% (dried material, NT)

form

solid

optical activity

[α]20/D +265±5°, c = 0.8% in ethanol (dry matter)

quality

crystallized

impurities

≤2% water, ~10% hydroquinidine (HPLC)

mp

168-172 °C (lit.)

functional group

hydroxyl

SMILES string

COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1

InChI key

LOUPRKONTZGTKE-LHHVKLHASA-N

Gene Information

human ... ABCB1(5243), CYP2D6(1565), CYP3A4(1576), KCNH1(3756), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)

General description

Quinidine is an isomer of quinine.

Application

Quinidine may be used in the preparation of O-trimethylsilylquinidine by reacting trimethylsilyl chloride.

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

Other Notes

Chiral catalyst, used e.g. in highly enantioselective [2+2] cycloadditions

Still not finding the right product?

Explore all of our products under Quinidine

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCH8905
BCBZ3910
BCBP9110V
BCBB6721
BCBB4073

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The Journal of Organic Chemistry, 50, 1977-1977 (1985)
P.E. Ketelaar et al.
Tetrahedron Letters, 26, 4665-4665 (1985)
Organocatalytic enantioselective synthesis of bicyclic ?-lactones from aldehyde acids via nucleophile-catalyzed aldol-lactonization (NCAL).
Nguygen et al.
Organic Syntheses, 88, 121-137 (2011)
View All Related Papers