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Merck

379115

DCC

1.0 M in methylene chloride, for peptide synthesis

Synonym(s):

N,N′-Dicyclohexylcarbodiimide solution

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About This Item

Linear Formula:
C6H11N=C=NC6H11
CAS Number:
538-75-0
Molecular Weight:
206.33
UNSPSC Code:
12352111
PubChem Substance ID:
24863614
NACRES:
NA.22
MDL number:
MFCD00011659

Key Documents

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Product Name

DCC, 1.0 M in methylene chloride

SMILES string

C1CCC(CC1)N=C=NC2CCCCC2

InChI

1S/C13H22N2/c1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13/h12-13H,1-10H2

InChI key

QOSSAOTZNIDXMA-UHFFFAOYSA-N

form

liquid

reaction suitability

reaction type: Coupling Reactions

concentration

1.0 M in methylene chloride

density

1.247 g/mL at 25 °C

application(s)

peptide synthesis

Quality Level

200

Gene Information

human ... EPHX2(2053)
mouse ... Ephx2(13850)

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Related Categories

Application

DCC (N,N′-Dicyclohexylcarbodiimide) is mainly used to mediate peptide coupling and also to activate carboxylic acids for esterification.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ4378
MKCZ0471
MKCX8138
MKCX5706
MKCW4597

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Liposomes containing alkylated methotrexate analogues for phospholipase A 2 mediated tumor targeted drug delivery.
Kaasgaard T, et al.
Chemistry and Physics of Lipids, 157(2), 94-103 (2009)
Effects of amounts of additives on peptide coupling mediated by a water?soluble carbodiimide in alcohols.
Nozaki S.
The Journal of Peptide Research, 54(2), 162-167 (1999)
Kenji Mizutani et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(33), 13474-13479 (2011-08-05)
The prokaryotic V-ATPase of Enterococcus hirae, closely related to the eukaryotic enzymes, provides a unique opportunity to study the ion-translocation mechanism because it transports Na(+), which can be detected by radioisotope (22Na(+)) experiments and X-ray crystallography. In this study, we
Marten Staal et al.
Plant physiology, 155(4), 2049-2055 (2011-02-02)
In Arabidopsis (Arabidopsis thaliana; Columbia-0) roots, the so-called zone of cell elongation comprises two clearly different domains: the transition zone, a postmeristematic region (approximately 200-450 μm proximal of the root tip) with a low rate of elongation, and a fast
Radostina K Manova et al.
Langmuir : the ACS journal of surfaces and colloids, 28(23), 8651-8663 (2012-05-31)
Cu-free "click" chemistry is explored on silicon nitride (Si(3)N(4)) surfaces as an effective way for oriented immobilization of biomolecules. An ω-unsaturated ester was grafted onto Si(3)N(4) using UV irradiation. Hydrolysis followed by carbodiimide-mediated activation yielded surface-bound active succinimidyl and pentafluorophenyl
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