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Merck

394866

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

synthesis grade

Synonym(s):

N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
24589-78-4
Molecular Weight:
199.25
UNSPSC Code:
41115710
NACRES:
NA.22
PubChem Substance ID:
24864622
EC Number:
246-331-6
Beilstein/REAXYS Number:
1941550
MDL number:
MFCD00000411

Product Name

N-Methyl-N-(trimethylsilyl)trifluoroacetamide, synthesis grade

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

grade

derivatization grade ((GC derivatization))
synthesis grade

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

assay

≥98%

form

liquid

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

refractive index

n20/D 1.38 (lit.)

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

storage temp.

2-8°C

Quality Level

100

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Application

Silylating agent used to form volatile derivatives for GC-MS analysis.
Improved silylation procedure for simultaneous detection of steroid hormones 17-α-ethynylestradiol and estrone.

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.

Other Notes

Reagent for trimethylsilyl.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

77.0 °F - closed cup

flash_point_c

25 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN9281
BCCM7637
BCCL3951
BCCM1869
BCCK4757

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Tina Kosjek et al.
Environment international, 31(5), 679-685 (2005-05-25)
Pharmacologically active substances used to treat human and animal illnesses can enter the aquatic environment via effluents from wastewater treatment plants or in the case of veterinary drugs directly through liquid manure discharge. Some of these substances enter the environment
Stina K Lien et al.
Journal of chromatography. A, 1247, 118-124 (2012-06-15)
GC-MS analysis of silylated metabolites is a sensitive method that covers important metabolite groups such as sugars, amino acids and non-amino organic acids, and it has become one of the most important analytical methods for exploring the metabolome. Absolute quantitative
Hee-Kyung Jeon et al.
Journal of chromatography. A, 1131(1-2), 192-202 (2006-08-08)
A novel method has been developed to simultaneously determine and quantify seven organic UV filters employing liquid (solid)-liquid extraction, derivatization with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA) and gas chromatography with mass spectrometric detection in various environmental matrices. The UV filters determined were:
Iria González-Mariño et al.
Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)
An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives
L Damasceno et al.
Journal of mass spectrometry : JMS, 35(11), 1285-1294 (2000-12-13)
An evaluation of derivatization procedures for the detection of beta(2)-agonists is presented. The study was performed with the beta(2)-agonists bambuterol, clenbuterol, fenoterol, formoterol, salbutamol, salmeterol and terbutaline. Different derivatizating agents were employed, aiming to obtain derivatives with high selectivity to
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