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Merck

86720

Tetraethylthiuram disulfide

≥97.0% (S)

Synonym(s):

Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Linear Formula:
(C2H5)2NCSS2CSN(C2H5)2
CAS Number:
97-77-8
Molecular Weight:
296.54
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
57653188
EC Number:
202-607-8
Beilstein/REAXYS Number:
1712560
MDL number:
MFCD00009048

Key Documents

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Product Name

Tetraethylthiuram disulfide, ≥97.0% (S)

InChI key

AUZONCFQVSMFAP-UHFFFAOYSA-N

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

SMILES string

CCN(CC)C(=S)SSC(=S)N(CC)CC

assay

≥97.0% (S)

form

powder

mp

69-71 °C (lit.)

functional group

amine
disulfide

Quality Level

200

Gene Information

human ... ALDH2(217), CYP1A2(1544)

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Related Categories

Application

Alcohol dehydrogenase inhibitor.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM3881
BCCK2357
BCCG9745
BCCD7771
BCBN4962V

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Beatriz Mothe et al.
The Journal of antimicrobial chemotherapy, 70(6), 1833-1842 (2015-03-01)
The safety, immunogenicity, impact on the latent reservoir and rebound of viral load after therapeutic HIV-1 vaccination with recombinant modified vaccinia Ankara-based (MVA-B) HIV-1 vaccine expressing monomeric gp120 and the fused Gag-Pol-Nef polyprotein of clade B with or without a
Peter M Meggyesy et al.
Molecules (Basel, Switzerland), 25(21) (2020-10-31)
The therapeutic utility of the copper ionophore disulfiram was investigated in a diet-induced obesity mouse model (C57BL/6J background), both through administration in feed (0.05 to 1% (w/w)) and via oral gavage (150 mg/kg) for up to eight weeks. Mice were
Joanna Triscott et al.
Oncotarget, 3(10), 1112-1123 (2012-10-11)
Glioblastomas (GBM) are associated with high rates of relapse. These brain tumors are often resistant to chemotherapies like temozolomide (TMZ) and there are very few treatment options available to patients. We recently reported that polo-like kinase-1 (PLK1) is associated with
Martin Loss et al.
Transplantation, 95(9), 1134-1141 (2013-02-26)
The majority of pancreases, offered in allocation, are discarded. This pancreas underutilization is not well understood yet. We analyzed the detailed allocation protocols of all Eurotransplant-registered German whole-pancreas donors (2005-2009; n=1758). Outcome measures included donor characteristics, number of refusals per
Meriem Gaval-Cruz et al.
Molecular interventions, 9(4), 175-187 (2009-09-02)
The anti-alcoholism drug disulfiram (Antabuse), which is an inhibitor of aldehyde dehydrogenase, induces an aversive reaction to alcohol consumption and thereby helps patients reduce alcohol intake. Recent clinical trials, initiated to investigate whether disulfiram could be used to treat individuals
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