F3401
2-Fluoroaniline
≥99%
Synonym(s):
1-Amino-2-fluorobenzene
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About This Item
Linear Formula:
FC6H4NH2
CAS Number:
Molecular Weight:
111.12
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
EC Number:
206-478-9
Beilstein/REAXYS Number:
1524219
MDL number:
Assay:
≥99%
assay
≥99%
refractive index
n20/D 1.544 (lit.)
bp
182-183 °C (lit.)
mp
−29 °C (lit.)
density
1.151 g/mL at 25 °C (lit.)
SMILES string
Nc1ccccc1F
InChI
1S/C6H6FN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2
InChI key
FTZQXOJYPFINKJ-UHFFFAOYSA-N
Biochem/physiol Actions
The metabolism and excretion of the xenobiotic compound 2-fluoroaniline is important due to human exposure in manufacturing. It is found to be very efficiently metabolized, primarily by 4-hydroxylation with subsequent sulfate or glucuronide formation. N-Acetylation is also observed. At least 80% of the dose is excreted in the urine within 24 hr. 2-Fluoroaniline exerts its nephrotoxic effect through 4-hyroxylation and subsequent p-benzoquinonimine formation.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1C - STOT RE 2
target_organs
Blood,hematopoietic system
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
140.0 °F - closed cup
flash_point_c
60 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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A L Sharma et al.
Applied biochemistry and biotechnology, 96(1-3), 155-165 (2002-01-11)
Poly(2-fluoroaniline) was prepared by both chemical and electrochemical polymerization in acidic medium. Characterization of poly(2-fluoroaniline) was accomplished experimentally using ultraviolet-visible, Fourier transform infrared, differential scanning calorimetry, thermal gravimetric analysis, and X-ray diffraction techniques, respectively. Scanning electron microscopy studies revealed globular
M Arivazhagan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 668-676 (2012-08-14)
The Fourier transform infrared (FT-IR) and Fourier transform Raman (FT-Raman) spectra of 4-chloro-2-fluoroaniline (CFA) have been recorded and analyzed. The equilibrium geometry, bonding features and harmonic vibrational frequencies have been investigated with the help of ab initio and density functional
M A Valentovic et al.
Toxicology, 75(2), 121-131 (1992-11-01)
Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with