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About This Item
Empirical Formula (Hill Notation):
C43H69D7O2
CAS Number:
Molecular Weight:
632.11
MDL number:
NACRES:
NA.25
UNSPSC Code:
41141804
Assay:
>99% (TLC)
Form:
powder
Product Name
16:0 cholesteryl-d7 ester, Avanti Research™ - A Croda Brand 700149P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (700149P-10mg), pkg of 1 × 25 mg (700149P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700149P
shipped in
dry ice
storage temp.
−20°C
General description
Cholesteryl palmitate is a cholesteryl ester. 16:0 cholesteryl-d7 ester is the deuterated form of cholesteryl palmitate or 16:0 cholesteryl ester.
Application
16:0 cholesteryl-d7 ester has been used:
- in plasma sample preparation for tandem mass spectrometry analysis (MS/MS)
- as an internal standard in mass spectrometry for quantification of nerve lipids from mice
- as an internal standard in time-of-flight mass spectrometry (TOFMS) for the quantification of serum extracellular vesicles (EVs) lipids
- as an external calibrator and internal spiking standard in tandem mass spectroscopy measurements
- in liposome preparation for retinyl ester hydrolase (REH) and cholesteryl esterase activity assay
Biochem/physiol Actions
Cholesteryl palmitate is associated with atherosclerotic plaque. Deuterated cholesteryl palmitate in used in reconstituting high-density lipoprotein (HDL). An elevated levels of the ratio of cholesteryl oleate to cholesteryl palmitate is implicated with apoptotic cell death in the atherosclerotic lesions.
Packaging
5 mL Amber Glass Screw Cap Vial (700149P-10mg)
5 mL Amber Glass Screw Cap Vial (700149P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
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Y I Parmar et al.
The Journal of biological chemistry, 258(3), 2000-2004 (1983-02-10)
Reconstituted high density lipoprotein has been prepared by sonication and preparative ultracentrifugation of mixtures containing the apoprotein of high density lipoprotein, egg phosphatidylcholine, cholesteryl oleate, and acyl chain deuterated cholesteryl palmitate in aqueous buffer. The resulting structures have a size
Suming Chen et al.
Journal of circulating biomarkers, 8, 1849454419879848-1849454419879848 (2019-10-22)
There is a wide variety of extracellular vesicles (EVs) that differ in size and cargo composition. EVs isolated from human plasma or serum carry lipid, protein, and RNA cargo that provides insights to the regulation of normal physiological processes, and
Maidina Tuohetahuntila et al.
The Journal of biological chemistry, 292(30), 12436-12448 (2017-06-16)
Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerols (TAGs), cholesteryl esters, and retinyl esters (REs). We previously provided evidence for the presence