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Merck

05-796

Anti-Akt1/PKBα Antibody, clone AW24, rabbit monoclonal

clone AW24, Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-Akt1/PKBα Antibody, clone AW24, rabbit monoclonal, clone AW24, Upstate®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

AW24, monoclonal

species reactivity

human, mouse, rat

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_005163

UniProt accession no.

P31749

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... AKT1(207)

Physical form

Format: Purified
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Protein A purified

Analysis Note

routinely evaluated by immunoblot on RIPA lysates from human HEK293 cells

Application

Detect Akt1/PKBα using this Anti-Akt1 Antibody, clone AW24 validated for use in IP & WB.
Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling

Biochem/physiol Actions

Akt1/PKBα

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

~60kDa

Immunogen

Peptide (C-RPHFPQFSYSASGTA) corresponding to the C-terminal (residues 466-480) of rat Akt1/PKBα

Preparation Note

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

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A proposed mechanism underlying the effect of bacillus Calmette-Guérin (BCG) treatment for bladder cancer cells is as follows: BCG-induced crosslinking of cell-surface receptors results in the activation of signaling cascades, including cell-cycle regulators. However, the clinical significance of cell-cycle regulators
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Choi, JC; Muchir, A; Wu, W; Iwata, S; Homma, S; Morrow, JP; Worman, HJ
Science Translational Medicine null
Toshitaka Uehara et al.
Cytotechnology, 75(1), 49-62 (2023-01-31)
The standard treatment for non-muscle-invasive bladder cancer is intravesical Bacillus Calmette-Guérin (BCG) therapy, which is considered the only intravesical therapy that reduces the risk of progression to muscle-invasive cancer. BCG unresponsiveness, in which intravesical BCG therapy is ineffective, has become
Demetris C Iacovides et al.
Molecular & cellular proteomics : MCP, 12(11), 3210-3220 (2013-08-10)
Breast cancer subtype-specific molecular variations can dramatically affect patient responses to existing therapies. It is thought that differentially phosphorylated protein isoforms might be a useful prognostic biomarker of drug response in the clinic. However, the accurate detection and quantitative analysis
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Global Trade Item Number

SKUGTIN
05-79604053252738951

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