205548

Caffeine

Name: Caffeine
Brand: MM

≥99% (HPLC), central nervous system stimulant, solid

Synonym(s):

Caffeine, 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₀N₄O₂

CAS Number:

58-08-2

Molecular Weight:

194.19

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00005758

Product Name

Caffeine, Trimethylated xanthine that acts as a potent central nervous system stimulant.

SMILES string

[n]1(c2c(nc1)N(C(=O)N(C2=O)C)C)C

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

description

Merck USA index - 14, 1636

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

chloroform: 50 mg/mL

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Cell permeable: no

Primary Target
Potent central nervous system stimulant

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Harmful (C)

Other Notes

Zhen, W., and Vaugha, A. T. 1995. Radiat. Res.141, 170.
Howell, L. L. 1993. Cancer Res.54, 4993.
Traganos, F., et al. 1993. Cancer Res.53, 4613.
Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

General description

Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca²⁺by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by Camptothecin (Cat. No. 208925 ) and topotecan in HL-60 cells.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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