219421

Cathepsin L Inhibitor I

Name: Cathepsin L Inhibitor I
Brand: MM

The Cathepsin L Inhibitor I, also referenced under CAS 108005-94-3, controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Cathepsin L Inhibitor I, Z-FF-FMK

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₇FN₂O₄

CAS Number:

108005-94-3

Molecular Weight:

462.51

MDL number:

MFCD24369030

UNSPSC Code:

12352200

NACRES:

NA.77

Product Name

Cathepsin L Inhibitor I, The Cathepsin L Inhibitor I, also referenced under CAS 108005-94-3, controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

InChI key

CAILNONEKASNSH-UHFFFAOYSA-N

InChI

1S/C27H27FN2O4/c28-18-25(31)23(16-20-10-4-1-5-11-20)29-26(32)24(17-21-12-6-2-7-13-21)30-27(33)34-19-22-14-8-3-9-15-22/h1-15,23-24H,16-19H2,(H,29,32)(H,30,33)

SMILES string

FCC(=O)C(NC(=O)C(NC(=O)OCc3ccccc3)Cc2ccccc2)Cc1ccccc1

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated

color

white

solubility

DMSO: 20 mM

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

Analysis Note

single spot by TLC

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cathepsin L

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent, cell-permeable and irreversible inhibitor of cathepsin L.

A potent, cell-permeable, and irreversible inhibitor of Cathepsin L (Cat. No. 219402 ).

Other Notes

Ravanko, K., et al. 2004. Cancer Res.64, 8831.
Esser, R.E., et al. 1994. Arthritis Rheum. 37, 236.
Shaw, E., et al. 1993. FEBS Lett.334, 340.

Z-Phe-Phe-CH₂F

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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