513040-M
PD 174265
A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM).
Synonym(s):
PD 174265, 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
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About This Item
Empirical Formula (Hill Notation):
C17H15BrN4O
CAS Number:
Molecular Weight:
371.23
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 200 mg/mL
storage temp.
−20°C
SMILES string
Brc1cc(ccc1)Nc2ncnc3c2cc(cc3)NC(=O)CC
InChI
1S/C17H15BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h3-10H,2H2,1H3,(H,21,23)(H,19,20,22)
InChI key
WUPUZEMRHDROEO-UHFFFAOYSA-N
General description
A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).
Biochem/physiol Actions
Primary Target
EGFR tyrosine kinase activity
EGFR tyrosine kinase activity
Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
495.3 °F
flash_point_c
257.4 °C
Certificates of Analysis (COA)
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