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Merck

8.52226

Fmoc-Phe-OPfp

Novabiochem®

Synonym(s):

Fmoc-Phe-OPfp, N-α-Fmoc-L-phenylalanine pentafluorophenyl ester

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About This Item

Empirical Formula (Hill Notation):
C30H20F5NO4
CAS Number:
Molecular Weight:
553.48
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
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Quality Segment

product line

Novabiochem®

assay

≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

145-160 °C

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

15-25°C

SMILES string

Fc1c(c(c(c(c1F)F)OC(=O)[C@@H](NC(=O)OCC3c4c(cccc4)c5c3cccc5)Cc2ccccc2)F)F

InChI

1S/C30H20F5NO4/c31-23-24(32)26(34)28(27(35)25(23)33)40-29(37)22(14-16-8-2-1-3-9-16)36-30(38)39-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h1-13,21-22H,14-15H2,(H,36,38)/t22-/m0/s1

InChI key

WKHPSOMXNCTXPK-QFIPXVFZSA-N

General description

Pre-formed pentafluorophenyl ester for coupling of phenylalanine amino-acid residues by Fmoc SPPS. Use enables bromophenol blue monitoring of amide bond formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in chloroform): -22.0 - -18.0 °
DCU (DC (0004)): ≤ 2 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (0,5 mmole in 3 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1514

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3



Certificates of Analysis (COA)

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