AB3314P
Anti-Monocarboxylate Transporter 4 Antibody
Chemicon®, from rabbit
Synonym(s):
MCT4
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Product Name
Anti-Monocarboxylate Transporter 4 Antibody, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC16A3(9123)
Application
Detect Monocarboxylate Transporter 4 using this Anti-Monocarboxylate Transporter 4 Antibody validated for use in ELISA & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
Western blot: 1-5 mg/mL using ECL.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by the end user.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Recognizes rat Monocarboxylate Transporter 4 (MCT4/MOT4/ SLC16A3). The immunogen shows no significant sequence homology with other MCT. MCT4 is prominently expressed in skeletal muscle and other cells with high glycolytic rate such as tumors cells and white blood cells suggesting an important role in lactic acid efflux.
Note: According to new nomenclature, the old MCT3 has now been reclassified as MCT4. Consult Halestrap and Price (1999) Biochem. J. 343:281-299.
SPECIES REACTIVITIES:
Rat. The immunogen sequence is 100% conserved in human and mouse and 78% conserved in chicken. Reactivity with other species has not been confirmed.
Note: According to new nomenclature, the old MCT3 has now been reclassified as MCT4. Consult Halestrap and Price (1999) Biochem. J. 343:281-299.
SPECIES REACTIVITIES:
Rat. The immunogen sequence is 100% conserved in human and mouse and 78% conserved in chicken. Reactivity with other species has not been confirmed.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
A 19 amino acid peptide sequence near the C-terminus of rat/human/mouse MCT4.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB3546P
Physical form
Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA and 0.05% sodium azide.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Yasna Contreras-Baeza et al.
The Journal of biological chemistry, 294(52), 20135-20147 (2019-11-14)
Monocarboxylate transporter 4 (MCT4) is an H+-coupled symporter highly expressed in metastatic tumors and at inflammatory sites undergoing hypoxia or the Warburg effect. At these sites, extracellular lactate contributes to malignancy and immune response evasion. Intriguingly, at 30-40 mm, the
Claire Thomas et al.
American journal of physiology. Endocrinology and metabolism, 293(4), E916-E922 (2007-07-05)
This study investigated the effects of high-intensity training, with or without induced metabolic alkalosis, on lactate transporter (MCT1 and MCT4) and sodium bicarbonate cotransporter (NBC) content in rat skeletal muscles. Male Wistar rats performed high-intensity training on a treadmill 5
A Nagai et al.
Placenta, 31(2), 126-133 (2009-12-22)
Lactate plays an important role as an alternative energy substrate, especially in conditions with a decreased utility of glucose. Proton-coupled monocarboxylate transporters (MCTs) are essential for the transport of lactate, ketone bodies, and other monocarboxylates through the plasma membrane and
Anjali A Sarkar et al.
Placenta, 38, 16-23 (2016-02-26)
The labyrinthine zone of the placenta is where exchange of nutrients and waste occurs between maternal and fetal circulations. Proper development of the placental labyrinth is essential for successful growth of the developing fetus and abnormalities in placental development are
J S Gilbert et al.
Placenta, 33(2), 100-105 (2011-12-22)
While utero-placental insufficiency is associated with adverse outcomes for both mother and fetus, many of the maternal-fetal adaptations during pregnancy in models of fetal compromise remain unclear. The purpose of this study was to determine if chronically reduced uterine perfusion
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| AB3314P | 04053252586149 |
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