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HBNMAG-51K

MILLIPLEX® Human Bone Panel

Configurable Human Bone 13-Plex Panel

Synonym(s):

human bone metabolic biomarkers immunoassay panel, luminex human bone metabolism multiplex assay, millipore human bone metabolic biomarkers multiplex kit, bone turnover assay overview, human bone biomarker panel, human bone metabolism assay, inflammation and bone health panel, skeletal disease multiplex kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Key Documents

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Product Name

MILLIPLEX® Human Bone Panel,

species reactivity

human

Quality Level

200

description

Configurable Human Bone 13-Plex Panel

assay range

accuracy: 82-97%, standard curve range: 0.24-1,000 pg/mL
(TNFα), standard curve range: 1-3,000 pg/mL
(IL-1β), standard curve range: 1-6,000 pg/mL
(ACTH & IL-6), standard curve range: 146-600,000 pg/mL
(OC), standard curve range: 24-100,000 pg/mL
(SOST), standard curve range: 37-150,000 pg/mL
(FGF-23), standard curve range: 49-200,000 pg/mL
(Leptin), standard curve range: 5-20,000 pg/mL
(DKK-1), standard curve range: 5-20,000 pg/mL
(PTH), standard curve range: 61-250,000 pg/mL
(Insulin), standard curve range: 7-30,000 pg/mL
(OPG), standard curve range: 98-400,000 pg/mL
(OPN)

technique(s)

multiplexing: suitable

input

serum plasma (cell culture supernatants, tissue/cell extracts)

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

General description

Bone health is regulated by a complex interplay of hormonal, inflammatory, and metabolic signals. This panel—ACTH, DKK1, FGF-23, IL-1β, IL-6, Insulin, Leptin, Osteocalcin (OC), Osteopontin (OPN), Osteoprotegerin (OPG), PTH, Sclerostin (SOST), and TNFα—captures key indicators of bone remodeling, endocrine function, and immune activity. These analytes are valuable for studying osteoporosis, arthritis, and metabolic bone diseases, supporting both translational and clinical research in skeletal biology.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 13 analytes in human serum, plasma, or cell/tissue culture supernatants.

Analytes Included: ACTH, DKK1, FGF-23, IL-1β, IL-6, Insulin, Leptin, Osteocalcin (OC), Osteopontin (OPN), Osteoprotegerin (OPG), PTH, Sclerostin (SOST), TNFα

Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Features:
  • Targets biomarkers involved in bone remodeling, endocrine regulation, and inflammation
  • Includes 13 analytes relevant to skeletal health, metabolic activity, and immune signaling
  • Multiplex format enables simultaneous detection from minimal sample volume
  • Compatible with human serum, plasma, and cell/tissue culture supernatants
  • Designed for research in osteoporosis, arthritis, endocrine disorders, and bone metabolism
Benefits:
  • Provides a comprehensive profile of bone turnover and inflammatory biomarkers
  • Supports investigation of skeletal disease mechanisms and endocrine regulation
  • Facilitates evaluation of therapeutic interventions and disease progression
  • Enables high-throughput analysis with reduced sample and reagent use
  • Delivers reproducible, sensitive results for translational and clinical research

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Certificates of Analysis (COA)

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Fawaz Y Azizieh et al.
Biomarker insights, 14, 1177271919843825-1177271919843825 (2019-08-28)
Receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and oxidative stress markers are suggested to contribute to bone loss in osteoporosis that occurs in menopause. However, the association between these markers and bone mineral density (BMD) is controversial.
Chiara Giannasi et al.
International journal of medical sciences, 16(1), 23-32 (2019-01-22)
Bisphosphonates (BPs) represent the first-line treatment for a wide array of bone disorders. Despite their well-known action on osteoclasts, the effects they induce on osteoblasts are still unclear. In order to shed light on this aspect we evaluated the impact
Sharon M Moe et al.
Circulation, 132(1), 27-39 (2015-06-11)
Patients with kidney disease have disordered bone and mineral metabolism, including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These elevated concentrations are associated with cardiovascular and all-cause mortality. The objective was to determine the effects of the calcimimetic cinacalcet
Nigel Kurgan et al.
Frontiers in endocrinology, 11, 531926-531926 (2020-12-29)
In adults, excess adiposity has been associated with low-grade, chronic inflammation and compromised bone health, but less is known about these linkages in children. The purpose of this study was to compare the circulating levels of inflammatory cytokines, adipokines, osteokines
Tsang-Hai Huang et al.
Journal of musculoskeletal & neuronal interactions, 20(2), 206-215 (2020-06-03)
The present study determined time-course changes in plasma bone-specific and -related markers following a bout of maximal eccentric contractions (MaxEC) of bilateral knee extensors (KE) and flexors (KF). Sedentary young men (n=30) performed a bout of 10 sets of 10
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Global Trade Item Number

SKUGTIN
HBNMAG-51K-1104053252799990
HBNMAG-51K-1304053252800016
HBNMAG-51K-0604053252799945
HBNMAG-51K-0504053252799938
HBNMAG-51K-0304053252799914
HBNMAG-51K-1004053252799983
HBNMAG-51K-1204053252800009
HBNMAG-51K-0804053252799969
HBNMAG-51K-0704053252799952
HBNMAG-51K-0904053252799976
HBNMAG-51K-0404053252799921
HBNMAG-51K-0204053252799907
HBNMAG-51K-0104053252799891

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