03439
N-Ethyldiisopropylamine solution
~2 M in 1-methyl-2-pyrrolidinone, solution, suitable for peptide synthesis
Synonym(s):
N,N-Diisopropylethylamine, DIPEA, Hünig’s base
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About This Item
Empirical Formula (Hill Notation):
C8H19N
CAS Number:
Molecular Weight:
129.24
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Beilstein/REAXYS Number:
4124745
Form:
liquid
Product Name
N-Ethyldiisopropylamine solution, suitable for peptide synthesis, ~2 M in 1-methyl-2-pyrrolidinone
form
liquid
Quality Level
concentration
~2 M in 1-methyl-2-pyrrolidinone
impurities
≤0.2% water (KFT)
refractive index
n20/D 1.454
application(s)
peptide synthesis
functional group
amine
SMILES string
CCN(C(C)C)C(C)C
InChI
1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3
InChI key
JGFZNNIVVJXRND-UHFFFAOYSA-N
General description
N-Ethyldiisopropylamine (EDIA) reacts with monoactivated Michael acceptors to afford symmetrical sulfones.
Application
N,N-Diisopropylethylamine (DIPEA), also known as Hünig′s base, is a sterically hindered amine. It is commonly employed as a base in peptide synthesis. Additionally, DIPEA is also used in the Pd-catalyzed cross-coupling reactions, which include Heck coupling and Sonagashira coupling reactions.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 3 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
73.4 °F
flash_point_c
23 °C
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Eugene F, et al.
The Journal of Organic Chemistry, 59(9), 2599-2603 (1994)
Tristan Doussineau et al.
Journal of colloid and interface science, 339(1), 266-270 (2009-08-15)
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J-N Volle et al.
Biosensors & bioelectronics, 19(5), 457-464 (2003-11-19)
We present a silicon chip-based approach for the enhanced sensitivity detection of surface-immobilized fluorescent molecules. Green fluorescent protein (GFP) is bound to the silicon substrate by a disuccinimidyl terephtalate-aminosilane immobilization procedure. The immobilized organic layers are characterized by surface analysis