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Merck

12279

1,2-Propanediol

analytical standard

Synonym(s):

1,2-PDO, Propylene glycol

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About This Item

Linear Formula:
CH3CH(OH)CH2OH
CAS Number:
57-55-6
Molecular Weight:
76.09
UNSPSC Code:
41116107
NACRES:
NA.24
E Number:
E490
PubChem Substance ID:
329749683
EC Number:
200-338-0
MDL number:
MFCD00064272
Beilstein/REAXYS Number:
1340498

Product Name

1,2-Propanediol, analytical standard

InChI key

DNIAPMSPPWPWGF-UHFFFAOYSA-N

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

SMILES string

CC(O)CO

grade

analytical standard

vapor density

2.62 (vs air)

vapor pressure

0.08 mmHg ( 20 °C)

assay

≥99.7% (GC)

autoignition temp.

779 °F

shelf life

limited shelf life, expiry date on the label

expl. lim.

12.5 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.432 (lit.)
n20/D 1.433

bp

187 °C (lit.)

mp

−60 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
environmental
flavors and fragrances
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

format

neat

Quality Level

100

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Application

1,2-Propanediol may be used as an analyte protectant for the gas chromatography-mass spectrometric detection of environmental contaminants in honey, honeybees and pollens. It is also used as an analytical reference standard for the quantification of the analyte in biological fluids using headspace-gas chromatography (HS-GC) technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

1,2-Propanediol is a compound found to be chemically similar to ethylene glycol and is widely used in automobile antifreeze, activated charcoal preparations, cosmetics, beverages, ointments, etc. It is used as a diluent for the intravenous preparations of poorly water-soluble drugs.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food.

Find all available reference materials for compounds listed in 10/2011 here

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

217.4 °F - closed cup

flash_point_c

103 °C - closed cup

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN9350
BCCM9150
BCCL7823
BCCJ8882
BCCK7579

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A rapid analysis of plasma/serum ethylene and propylene glycol by headspace gas chromatography
Ehlers A, et al.
SpringerPlus, 2(1), 203-203 (2013)
Multi-residue analysis of 80 environmental contaminants in honeys, honeybees and pollens by one extraction procedure followed by liquid and gas chromatography coupled with mass spectrometric detection.
Wiest L, et al.
Journal of Chromatography A, 1218(34), 5743-5756 (2011)
Gai Ling Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 84(1-2), 49-57 (2002-10-26)
To achieve a therapeutical effect of the anti-Parkinson's drug R-apomorphine via iontophoresis delivery, enhancement strategies in vitro were explored using three structurally related enhancers, lauric acid (LA), dodecyltrimethylammonium bromide (DTAB) and Laureth-3 oxyethylene ether (C(12)EO(3)). Human stratum corneum and shed
R S Rajasenan et al.
Toxicology and applied pharmacology, 135(1), 89-99 (1995-11-01)
Engrafting components of human immune systems in severe combined immunodeficient (SCID) mice has been utilized to investigate the pathogenesis of several human autoimmune diseases and may provide a model for studying idiosyncratic drug toxicity. The purpose of this investigation was
Carla Caddeo et al.
International journal of pharmaceutics, 443(1-2), 128-136 (2013-01-10)
Diclofenac-loaded phospholipid vesicles, namely conventional liposomes, ethosomes and PEVs (penetration enhancer-containing vesicles) were developed and their efficacy in TPA (phorbol ester) induced skin inflammation was examined. Vesicles were made from a cheap and unpurified mixture of phospholipids and diclofenac sodium;
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