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Merck

23131

Ethyl chloroformate

purum, ≥98.0% (GC)

Synonym(s):

Chloroformic acid ethyl ester

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About This Item

Linear Formula:
ClCOOC2H5
CAS Number:
541-41-3
Molecular Weight:
108.52
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
329752388
EC Number:
208-778-5
Beilstein/REAXYS Number:
385653
MDL number:
MFCD00000644
Assay:
≥98.0% (GC)
Form:
liquid

Key Documents

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Product Name

Ethyl chloroformate, purum, ≥98.0% (GC)

InChI key

RIFGWPKJUGCATF-UHFFFAOYSA-N

InChI

1S/C3H5ClO2/c1-2-6-3(4)5/h2H2,1H3

SMILES string

CCOC(Cl)=O

vapor density

3.74 (vs air)

vapor pressure

3.42 psi ( 20 °C)

grade

purum

assay

≥98.0% (GC)

form

liquid

autoignition temp.

842 °F

refractive index

n20/D 1.395 (lit.)
n20/D 1.396

bp

93 °C (lit.)

mp

−81 °C (lit.)

density

1.139 g/mL at 20 °C
1.135 g/mL at 25 °C (lit.)

functional group

chloro

Quality Level

100

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Application

  • GC-MS Analysis of Resveratrol Isomers in Red Wine: Application of ethyl chloroformate for derivatization of resveratrol isomers, enhancing GC-MS analysis effectiveness, crucial for quality control in food chemistry and drug discovery focusing on dietary supplements (Di Fabio et al., 2020).
  • Determination of Free Aromatic Carboxylic Acids and Phenols in Juices: Uses ethyl chloroformate for rapid GC-MS analysis, important for food safety and pharmacology by verifying phenolic bioactive compounds in consumer products (Incocciati et al., 2021).
  • Synthesis of Diaryl Ketones: Discusses a nickel-catalyzed method of synthesizing diaryl ketones using ethyl chloroformate, valuable for material science chemists developing new materials and pharmaceutical compounds (Shi & Hu, 2019).

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

60.8 °F

flash_point_c

16 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM9940
BCCD7968
BCCL3605
BCCJ1720
BCCD4304

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Man-Jeong Paik et al.
Journal of chromatography. A, 1214(1-2), 151-156 (2008-11-11)
N-ethoxycarbonylation was combined with (S)-1-phenylethylamidation for enantioseparation of amino acids by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) on achiral capillary columns. The method provided complete enantioseparations of 12 amino acids as diastereomeric N-ethoxycarbonyl/(S)-1-phenylethylamides with exceptional resolutions for proline
Jinmao You et al.
Analytica chimica acta, 658(1), 98-105 (2010-01-20)
An improved reagent named 2-[2-(dibenzocarbazole)-ethoxy] ethyl chloroformate (DBCEC-Cl) for the determination of aliphatic amines by high-performance liquid chromatography (HPLC) with fluorescence detection and post-column online atmospheric chemical ionization-mass spectrometry (APCI-MS) identification has been developed. DBCEC-Cl could easily and quickly label
Tan Guo et al.
Journal of the American Society for Mass Spectrometry, 18(5), 817-825 (2007-03-06)
Beta-methylamino-L-alanine (BMAA) is a neurotoxic amino acid that can be produced by cyanobacteria in aqueous environments. To analyze this compound by gas chromatography/mass spectrometry (GC/MS), BMAA must be derivatized to a nonpolar, volatile compound. This can be accomplished by reacting
Xianfu Gao et al.
Analytical biochemistry, 393(2), 163-175 (2009-07-04)
Fecal water is a complex mixture of various metabolites with a wide range of physicochemical properties and boiling points. The analytical method developed here provides a qualitative and quantitative gas chromatography/mass spectrometry (GC/MS) analysis, with high sensitivity and efficiency, coupled
P Husek et al.
Journal of chromatography. B, Biomedical sciences and applications, 693(2), 499-502 (1997-06-06)
Following deproteinization of plasma with organic solvents the supernatant was shaken with hexane and cation-exchange resin in an Eppendorf tube to remove fatty and amino acids and the medium was subjected to direct treatment with ethyl chloroformate under catalytic influence
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