N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Name: <I>N</I>-Methyl-<I>N</I>-(trimethylsilyl)trifluoroacetamide
Brand: SIAL

derivatization grade (GC derivatization), LiChropur^™, ≥98.5%

Synonym(s):

N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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About This Item

Linear Formula:

CF₃CON(CH₃)Si(CH₃)₃

CAS Number:

24589-78-4

Molecular Weight:

199.25

UNSPSC Code:

23151817

NACRES:

NA.22

PubChem Substance ID:

329761689

EC Number:

246-331-6

Beilstein/REAXYS Number:

1941550

MDL number:

MFCD00000411

Product Name

N-Methyl-N-(trimethylsilyl)trifluoroacetamide, derivatization grade (GC derivatization), LiChropur^™, ≥98.5%

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

grade

derivatization grade (GC derivatization)

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

assay

≥98.5% (GC)
≥98.5%

form

liquid

quality

LiChropur^™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)
n20/D 1.380

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

storage temp.

2-8°C

Quality Level

200

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Analytical Reagents

Chromatography & Spectroscopy Reagents

Application

Learn more in the Product Information

MSTFA may be used in silylation procedure to detemine steroid hormones 17α-ethinylestradiol (EE2) and estrone using GC-MS. MSTFA along with Trimethylsilyl chloride (TMCS) in eithyl acetate, acetonitrile and dichloromethane solvents leads to formation of trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) derivatives.

Suitable for the derivatization of amines, amino acids, carboxyl, hydroxyamines, indolalkylamine, n-nitrosoamino acids, nucleosides, phenolalkylamines, serotonin and tryptamine.

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a silylating reagent.

Other Notes

Powerful silylating agent

Reagent for N-acetyl-N, trifluoroacetyl, trimethylsilyl, N-trimethylsilyl-N-trifluoroacetyl, and O-trimethylsilyl (TMS)

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS02,GHS07

signalword

Warning

hcodes

H226,H315,H319,H335

pcodes

P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

77.0 °F - closed cup

flash_point_c

25 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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The Role of a Glucosinolate-Derived Nitrile in Plant Immune Responses.

Hieng-Ming Ting et al.

Frontiers in plant science, 11, 257-257 (2020-03-27)

Glucosinolates are defense-related secondary metabolites found in Brassicaceae. When Brassicaceae come under attack, glucosinolates are hydrolyzed into different forms of glucosinolate hydrolysis products (GHPs). Among the GHPs, isothiocyanates are the most comprehensively characterized defensive compounds, whereas the functional study of

Journal of Chromatography A, 115, 591-591 (1975)

J. Heberle et al.

Silylating Agents, 2nd ed. (1995)

M. Donike

Chromatographia, 9, 440-440 (1976)

Bundle sheath suberisation is required for C4 photosynthesis in a Setaria viridis mutant.

Florence R Danila et al.

Communications biology, 4(1), 254-254 (2021-02-28)

C4 photosynthesis provides an effective solution for overcoming the catalytic inefficiency of Rubisco. The pathway is characterised by a biochemical CO2 concentrating mechanism that operates across mesophyll and bundle sheath (BS) cells and relies on a gas tight BS compartment.

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