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Merck

69673

Homovanillic acid

analytical standard

Synonym(s):

4-Hydroxy-3-methoxyphenylacetic acid, HVA

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About This Item

Linear Formula:
HOC6H3(OCH3)CH2CO2H
CAS Number:
306-08-1
Molecular Weight:
182.17
UNSPSC Code:
77101502
NACRES:
NA.24
PubChem Substance ID:
329761856
EC Number:
206-176-7
Beilstein/REAXYS Number:
2213447
MDL number:
MFCD00004350

Product Name

Homovanillic acid, analytical standard

InChI

1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)

SMILES string

COc1cc(CC(O)=O)ccc1O

InChI key

QRMZSPFSDQBLIX-UHFFFAOYSA-N

grade

analytical standard

assay

≥97.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

142-145 °C (lit.)
142-145 °C

application(s)

pharmaceutical

format

neat

Quality Level

100

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Application

Homovanillic acid may be used as a reference standard in the determination of homovanillic acid in samples of human cerebrospinal fluid using gas chromatography coupled with electron capture detector.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN7521
BCCM9537
BCCL9201
BCCL1914
BCCJ1320

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On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorometric method.
Sjoquist B and Anggard E.
Life Sciences, 2(7), 448-458 (1963)
Kyung Tai Lee et al.
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The Journal of physiology, 592(17), 3767-3782 (2014-06-22)
We investigated the impact of cardiac reactive oxygen species (ROS) during the development of pressure overload-induced heart failure. We used our previously described rat model where transverse aortic constriction (TAC) induces compensated hypertrophy after 2 weeks, heart failure with preserved
Xiaoli Liu et al.
Neurotoxicity research, 38(1), 27-37 (2020-03-22)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the accumulation of Lewy bodies and loss of dopaminergic neurons in the substantia nigra pars compacta (SNpC). MPTP is widely used to generate murine PD model. In addition to classical motor
M A Aguilar et al.
Brain research bulletin, 113, 27-33 (2015-03-01)
Although the consumption of cocaine is frequent in young users of MDMA (3,4-methylenedioxymethamphetamine), the influence of exposure to cocaine on the rewarding effects of MDMA in adolescents has not been studied. The purpose of the present work was to evaluate
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