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Merck

75285

N′-Nitrosonornicotine

analytical standard

Synonym(s):

1-Nitroso-2-(3-pyridyl)pyrrolidine, 3-(1-Nitroso-2-pyrrolidinyl)pyridine, NNN

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About This Item

Empirical Formula (Hill Notation):
C9H11N3O
CAS Number:
80508-23-2
Molecular Weight:
177.20
NACRES:
NA.24
PubChem Substance ID:
329766318
UNSPSC Code:
41116107
MDL number:
MFCD00274581

Product Name

N′-Nitrosonornicotine, analytical standard

InChI

1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2

SMILES string

O=NN1CCCC1c2cccnc2

InChI key

XKABJYQDMJTNGQ-UHFFFAOYSA-N

grade

analytical standard

assay

≥99.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

2-8°C

Quality Level

100

Related Categories

Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Application

N′-Nitrosonornicotine may be used as an analytical reference standard for the analysis of total N-nitrosamines in wastewater treatment plants using liquid chromatography-high-resolution mass spectrometry (LC-HRMS).

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N′-Nitrosonornicotine is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5448
BCCL2217
BCCK5634
BCCK1178
BCCG5567

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Combining High-Resolution Mass Spectrometry and Chemiluminescence Analysis to Characterize the Composition and Fate of Total N-Nitrosamines in Wastewater Treatment Plants
Pu C, et al.
Environmental Science & Technology, 58, 17081-17091 (2024)
Huda Mahmoud et al.
Frontiers in microbiology, 8, 2063-2063 (2017-11-09)
Corals that naturally thrive under extreme conditions are gaining increasing attention due to their importance as living models to understand the impact of global warming on world corals. Here, we present the first metagenomic study of viral communities in corals
Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes
Patten JC, et al.
Carcinogenesis, 18(8), 1623-1630 (1997)
Marc Besson et al.
PloS one, 12(6), e0178795-e0178795 (2017-06-09)
For marine fishes with a bipartite life cycle, pelagic larval dispersal can shape the distribution, connectivity, composition and resilience of adult populations. Numerous studies of larval dispersal, and associated settlement and recruitment processes, have examined the relationship between population connectivity
Théo Araújo-Santos et al.
Scientific reports, 7(1), 4334-4334 (2017-07-01)
Visceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play a critical role in the development of this disease. Here, we perform a prospective exploratory study addressing whether simultaneous assessment of circulating levels of
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