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Merck

81942

Propionic anhydride

purum, ≥96.0% (NT)

Synonym(s):

Propanoic anhydride

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About This Item

Linear Formula:
(CH3CH2CO)2O
CAS Number:
123-62-6
Molecular Weight:
130.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
329769224
EC Number:
204-638-2
Beilstein/REAXYS Number:
507066
MDL number:
MFCD00009303

Key Documents

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Product Name

Propionic anhydride, purum, ≥96.0% (NT)

InChI key

WYVAMUWZEOHJOQ-UHFFFAOYSA-N

InChI

1S/C6H10O3/c1-3-5(7)9-6(8)4-2/h3-4H2,1-2H3

SMILES string

CCC(=O)OC(=O)CC

vapor density

4.5 (vs air)

vapor pressure

10 mmHg ( 57.7 °C)

grade

purum

assay

≥96.0% (NT)

form

liquid

autoignition temp.

545 °F

expl. lim.

11.9 %

refractive index

n20/D 1.404 (lit.)
n20/D 1.404

bp

167 °C (lit.)

mp

−43 °C (lit.)

solubility

H2O: decomposes (when in contact with water)

density

1.010 g/mL at 20 °C
1.015 g/mL at 25 °C (lit.)

functional group

anhydride
ester

Quality Level

200

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Application

Propionic anhydride can be used:
  • As an esterifying reagent in the modification of cassava starch by acylation reaction.
  • As a reactant along with anisole in the synthesis of 4-methoxypropiophenone using various solid acid catalysts via Friedel−Crafts acylation reaction.
  • As a reagent in the synthesis of cyanohydrin esters by treating KCN with aldehyde in presence of bimetallic titanium(salen) complex catalyst.

Other Notes

Sales restrictions may apply

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

165.2 °F - closed cup

flash_point_c

74 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP0101
BCCN8765
BCCN5264
BCCH3554
BCCG3100

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Modification of cassava starch by using propionic anhydride and properties of the starch-blended polyester polyurethane
Santayanon R and Wootthikanokkhan J
Carbohydrate Polymers, 51(1), 17-24 (2003)
Synthetic and mechanistic studies on asymmetric cyanohydrin synthesis using a titanium (salen) bimetallic catalyst
Belokon YN, et al.
Tetrahedron, 60(46), 10433-10447 (2004)
Dimensional stabilisation and strength of particleboard by chemical modification with propionic anhydride.
Papadopoulos AN & Gkaraveli A
European Journal of Wood and Wood Products, 61(2), 142-144 (2003)
Hyung Wook Nam et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 826(1-2), 91-107 (2005-09-17)
N-Terminal isotope tagging (NIT) is an important proteomic tool for quantifying proteins in complex mixtures. Here we describe a modified version of the isotope-coded propionylation procedure of Zhang et al. [Zhang et al., Rapid Commun. Mass Spectom. 16 (2002) 2325]
Mo Xu et al.
Methods in enzymology, 512, 29-55 (2012-08-23)
In eukaryotic cells, posttranslational modifications (PTMs) on histones regulate chromatin structure and thus impact nearly all chromatin-templated events, including replication, transcription, and DNA repair. During S phase, newly synthesized histones are deposited onto DNA, leading to dilution of total chromatin-associated
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