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Merck

A3669

Acebutolol hydrochloride

analytical standard

Synonym(s):

N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide

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About This Item

Empirical Formula (Hill Notation):
C18H28N2O4 · HCl
CAS Number:
34381-68-5
Molecular Weight:
372.89
NACRES:
NA.24
PubChem Substance ID:
329770842
UNSPSC Code:
41116107
EC Number:
251-980-3
MDL number:
MFCD00078860

Key Documents

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InChI key

KTUFKADDDORSSI-UHFFFAOYSA-N

InChI

1S/C18H28N2O4.ClH/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3;/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23);1H

SMILES string

Cl.CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(C)=O

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

Gene Information

human ... ADRB1(153)

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General description

Acebutolol hydrochloride is a β-adrenergic receptor blocker. It is used in the treatment of hypertension, cardiac arrhythmias and angina pectoris.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000427285
0000427285
056K1622V
056K1622

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The effect of acebutolol on the cerebral circulation of man.
Hares P, et al.
British Journal of Clinical Pharmacology, 4(3), 373-375 (1977)
2013 Nurse's Drug Handbook (2012)
Anna Kwiecień et al.
Journal of AOAC International, 91(2), 322-331 (2008-05-15)
The stability of atenolol, acebutolol, and propranolol was investigated in sodium hydroxide solutions at concentrations of 0.1, 0.3, 0.5, and 1 M at 3 temperatures ranging from 37 to 95 degrees C. The degradation processes that occurred in drugs under
Darren P Martin et al.
Archives of virology, 156(8), 1463-1469 (2011-04-13)
Recombination has profoundly shaped the evolution of viruses in the family Geminiviridae and has been studied extensively in the two best characterised geminivirus lineages: the dicotyledonous plant infecting begomoviruses and the monocotyledonous plant infecting mastreviruses. Here, we demonstrate that the
Pratap Neelakantan et al.
Blood, 121(14), 2739-2742 (2013-02-06)
Several groups have shown that that the BCR-ABL1 transcript level measured at 3 or 6 months after starting treatment with tyrosine kinase inhibitors strongly predicts clinical outcomes for patients with chronic myeloid leukemia. In this work, we asked whether the
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