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Merck

C1528

Cocaine hydrochloride solution

1.0 mg/mL in methanol, analytical standard, for drug analysis

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About This Item

Empirical Formula (Hill Notation):
C17H21NO4 · HCl
CAS Number:
53-21-4
Molecular Weight:
339.81
NACRES:
NA.24
PubChem Substance ID:
329774894
UNSPSC Code:
41116107
MDL number:
MFCD00058119

Key Documents

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Product Name

Cocaine hydrochloride solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis

InChI key

PIQVDUKEQYOJNR-VZXSFKIWSA-N

SMILES string

Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3

InChI

1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1

drug control

Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
kontrollierte Droge in Deutschland

Quality Level

200

concentration

1.0 mg/mL in methanol

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

2-8°C

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Application

Cocaine hydrochloride solution was used as a calibration standard to determine cocaine in human hair samples using gas chromatography/mass spectrometry (GC/MS). It may be used as a standard in the quantitative analysis of cocaine and its adulterants like lidocaine and livamisole using dragendorff reagent combined with paper spray ionization mass spectrometry.

General description

Cocaine is mostly commonly available as cocaine hydrochloride which is a white to off-white powder. It is taken by intranasal route. In some surgeries it is used as topical anaesthetic drug.

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
0000521588
0000521588
0000456027
0000456027
0000433618

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Quantification of cocaine and its adulterants (lidocaine and levamisole) using the Dragendorff reagent allied to paper spray ionization mass spectrometry
Santos.H, et al.
Analytical Methods : Advancing Methods and Applications (2017)
L Skender et al.
Forensic science international, 125(2-3), 120-126 (2002-03-23)
Hair of young subjects (N = 36) suspected for drug abuse was analysed for morphine, codeine, heroin, 6-acetylmorphine, cocaine, methadone, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA). The analysis of morphine, codeine, heroin, 6-acetylmorphine, cocaine, and methadone in
Billy T Chen et al.
Nature, 496(7445), 359-362 (2013-04-05)
Loss of control over harmful drug seeking is one of the most intractable aspects of addiction, as human substance abusers continue to pursue drugs despite incurring significant negative consequences. Human studies have suggested that deficits in prefrontal cortical function and
Elena Martín-García et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(10), 2317-2330 (2014-03-19)
High-frequency intake and high drug-induced seeking are associated with cocaine addiction in both human and animals. However, their relationships and neurobiological underpinnings remain hypothetical. The medial prefrontal cortex (mPFC), basolateral amygdala (BLA), and nucleus accumbens (NAc) have been shown to
Emmanuelle Jordi et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9511-9516 (2013-05-22)
Drugs of abuse, such as cocaine, induce changes in gene expression and epigenetic marks including alterations in histone posttranslational modifications in striatal neurons. These changes are thought to participate in physiological memory mechanisms and to be critical for long-term behavioral
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