H8000
L-Histidine
≥99% (TLC), ReagentPlus®
Synonym(s):
(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
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About This Item
Empirical Formula (Hill Notation):
C6H9N3O2
CAS Number:
Molecular Weight:
155.15
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
NACRES:
NA.26
EC Number:
200-745-3
MDL number:
Beilstein/REAXYS Number:
84088
Product Name
L-Histidine, ReagentPlus®, ≥99% (TLC)
Quality Level
product line
ReagentPlus®
assay
≥99% (TLC)
form
powder
color
white to off-white
mp
282 °C (dec.) (lit.)
solubility
0.5 M HCl: 50 mg/mL
application(s)
cell analysis
SMILES string
N[C@@H](Cc1c[nH]cn1)C(O)=O
InChI
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChI key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
Application
L-histidine has been used for the selection of transformed cells. It has also been used to study its effects on the formation of verteporfin cross-linked oligomers in cellular homogenates.
Biochem/physiol Actions
Precursor of histamine by action of histidine decarboxylase.
L-Histidine is an essential amino acid. It binds to metal ions and may aid in the transport of copper. Histidine is widely present at the active sites of enzymes. It also has a role in binding of heme groups, macromolecules and phosphate groups in the binding sites of proteins.
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Roger L. Lundblad
Chemical Reagents for Protein Modification (2014)
Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity
Eleni K
Scientific Reports (2017)
Kakulavarapu V Rama Rao et al.
The American journal of pathology, 176(3), 1400-1408 (2010-01-16)
Brain edema and the associated increase in intracranial pressure are potentially lethal complications of acute liver failure (ALF). Astrocyte swelling (cytotoxic edema) represents a significant component of the brain edema in ALF, and elevated blood and brain ammonia levels have