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Merck

PHR1161

Procaine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4-Aminobenzoic acid 2-diethylaminoethyl ester, p-Aminobenzoic acid diethylaminoethyl ester hydrochloride, Novocaine hydrochloride

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About This Item

Linear Formula:
H2NC6H4CO2CH2CH2N(C2H5)2·HCl
CAS Number:
51-05-8
Molecular Weight:
272.77
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823178
EC Number:
200-077-2
Beilstein/REAXYS Number:
3917802
MDL number:
MFCD00013000

Key Documents

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Product Name

Procaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

HCBIBCJNVBAKAB-UHFFFAOYSA-N

InChI

1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H

SMILES string

Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1564006

API family

procaine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

155-156 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Procaine hydrochloride can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by electrochemical, chemiluminescence, and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Procaine hydrochloride is a synthetic compound that belongs to the class of local anesthetic drugs. It has a structure similar to the natural compounds that participate in nerve impulse transmission. It shows interaction with the cellular membranes causing membrane lipids to expand, membrane-bound calcium to displace and change the structure of the proteins that are responsible for regulating the cell permeability and shape.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7177 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Induction of alkaline phosphatase in Escherichia coli: effect of procaine hydrochloride.
Tribhuwan RC and Pradhan DS
Journal of Bacteriology, 131(2), 431-437 (1977)
Effect of the presence of ?-cyclodextrin on the solution behavior of procaine hydrochloride. Spectroscopic and thermodynamic studies
Merino C, et al.
Langmuir, 16(4), 1557-1565 (2000)
Batch and flow-injection spectrophotometric determination of procaine HCl in pharmaceutical preparations via using diazotization and coupling reaction
Al-Ward HS, et al.
Baghdad Science Journal, 9(3), 521-531 (2012)
Improved therapeutic index of cisplatin by procaine hydrochloride
Esposito M, et al.
Journal of the National Cancer Institute, 82(8), 677-684 (1990)
Colorimetric Determination of Procaine hydrochloride in Pharmaceutical Preparations using Diazotization Coupling Reactions
Al-Uzri WA and Al-Heeti MI
International Journal of PharmTech Research, 8(1), 1042-1042 (2015)
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