RDD039
Imidazole
Molecular Biology, ≥99% (titration), free-flowing, Redi-Dri™
Synonym(s):
1, 3-diazole, 1,3-Diaza-2,4-cyclopentadiene, Glyoxaline
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About This Item
Empirical Formula (Hill Notation):
C3H4N2
CAS Number:
Molecular Weight:
68.08
NACRES:
NA.21
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
103853
MDL number:
eCl@ss:
39161001
grade
Molecular Biology
Quality Segment
vapor pressure
<1 mmHg ( 20 °C)
product line
Redi-Dri™
assay
≥99% (titration)
form
crystalline powder
quality
free-flowing
pH
6.2-7.8 (25 °C)
pKa (25 °C)
6.95
bp
256 °C (lit.)
mp
88-91 °C (lit.)
application(s)
diagnostic assay manufacturing
foreign activity
DNase, RNase and protease, none detected
SMILES string
c1c[nH]cn1
InChI
1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChI key
RAXXELZNTBOGNW-UHFFFAOYSA-N
General description
Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.
Application
Excellent for buffers in the range of pH 6.2-7.8
Imidazole has been used
- in the lysis, wash, and elution buffer for the purification of histidine tagged proteins
- in gradient for the purification of histidine tagged proteins using nickel affinity chromatography
- as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells
Biochem/physiol Actions
Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).
Features and Benefits
- Qualified for molecular biology applications, DNase, Rnase, and protease free
- Redi-Dri™ packaging controls moisture, eliminating clumps
- Crystalline powder remains free-flowing and much easier to use
- Safer to handle and weigh out for routine use in lab
- Less waste, loss of drying, while maintaining high quality
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Legal Information
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
293.0 °F - closed cup
flash_point_c
145 °C - closed cup
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