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10300

5α-Androstan-17β-ol-3-one

Name: 5&#945;-Androstan-17&#946;-ol-3-one
Brand: SIGMA

synthetic, ≥99.0% (TLC), Testosterone metabolite, powder

Synonym(s):

17β-Hydroxy-5α-androstan-3-one, 4,5α-Dihydrotestosterone, Androstanolone, Stanolone

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₃₀O₂

CAS Number:

521-18-6

Molecular Weight:

290.44

NACRES:

NA.77

PubChem Substance ID:

329749013

UNSPSC Code:

51111800

EC Number:

208-307-3

MDL number:

MFCD00003667

Beilstein/REAXYS Number:

2056371

Assay:

≥99.0% (TLC)

Form:

powder

Quality level:

200

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Properties

Product Name

5α-Androstan-17β-ol-3-one, purum, ≥99.0% (TLC)

biological source

synthetic

Quality Level

200

sterility

non-sterile

grade

purum

assay

≥99.0% (TLC)

form

powder

optical activity

[α]20/D +33±1°, c = 1% in ethanol

drug control

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

mp

178-183 °C

storage temp.

2-8°C

SMILES string

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CCC(=O)C2

InChI

1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1

InChI key

NVKAWKQGWWIWPM-ABEVXSGRSA-N

Description

Other Notes

Sales restrictions may apply

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pictograms

GHS08,GHS07,GHS09

signalword

Danger

hcodes

H302,H351,H360FD,H410

pcodes

P202 - P264 - P270 - P273 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality.

Bu B Yeap et al.

The Journal of clinical endocrinology and metabolism, 99(1), E9-18 (2013-11-22)

Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined. We assessed associations of T, DHT

Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice.

Takashi Taniguchi et al.

Arthritis & rheumatology (Hoboken, N.J.), 67(2), 517-526 (2014-11-12)

Fli-1, a potential predisposing factor for systemic sclerosis (SSc), is constitutively down-regulated in the lesional skin of patients with SSc by an epigenetic mechanism. To investigate the impact of Fli-1 deficiency on the induction of an SSc phenotype in various

Netrin-1 controls sympathetic arterial innervation.

Isabelle Brunet et al.

The Journal of clinical investigation, 124(7), 3230-3240 (2014-06-18)

Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue

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