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Merck

B1152

Betamethasone 17,21-dipropionate

≥97.0%, glucocorticoid, powder

Synonym(s):

9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

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About This Item

Empirical Formula (Hill Notation):
C28H37FO7
CAS Number:
5593-20-4
Molecular Weight:
504.59
NACRES:
NA.77
PubChem Substance ID:
24891564
UNSPSC Code:
12352200
EC Number:
227-005-2
MDL number:
MFCD00133140
Assay:
≥97.0%
Form:
powder
Quality level:
200

Key Documents

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Product Name

Betamethasone 17,21-dipropionate,

InChI key

UOCNBCVPZWLUKX-HOBFILNXSA-N

InChI

1S/C27H34ClFO7/c1-5-22(33)35-14-21(32)27(36-23(34)13-28)15(2)10-19-18-7-6-16-11-17(30)8-9-24(16,3)26(18,29)20(31)12-25(19,27)4/h8-9,11,15,18-20,31H,5-7,10,12-14H2,1-4H3/t15-,18-,19-,20-,24-,25-,26?,27-/m0/s1

SMILES string

[H][C@@]12C[C@H](C)[C@](OC(=O)CCl)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)C3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

assay

≥97.0%

form

powder

originator

Schering Plough

Quality Level

200

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General description

Betamethasone dipropionate is a class III intermediate potency synthetic fluorinated corticosteroid, which is used to treat psoriasis vulgaris. It is also used to treat seborrheic dermatitis and chronic hand eczema.

Biochem/physiol Actions

Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1B - STOT RE 2

target_organs

Liver,Kidney,Endocrine system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ8117
BCCK2556
BCCH6299
BCCD7513
BCCB3714

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Seborrheic dermatitis
Gupta AK and Bluhm R
Journal of the European Academy of Dermatology and Venereology : JEADV, 18(1), 13-26 (2004)
Comparison of cyclosporine and topical betamethasone-17, 21-dipropionate in the treatment of severe chronic hand eczema.
Granlund H, et al.
Acta Dermato-Venereologica, 76(5), 371-376 (1996)
Catherine Queille-Roussel et al.
The Journal of dermatological treatment, 24(4), 250-254 (2011-11-23)
The efficacy and safety of calcipotriol plus betamethasone dipropionate ointment in the treatment of psoriasis vulgaris has consistently been demonstrated in several clinical trials. For treatment of scalp psoriasis, more convenient formulations are required. Therefore, new lipophilic alcohol-free gel formulations
Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis
Papp KA, et al.
Journal of the American Academy of Dermatology, 48(1), 48-54 (2003)
Naresh Punwani et al.
Journal of the American Academy of Dermatology, 67(4), 658-664 (2012-01-28)
Janus-associated kinases (JAKs) are involved in signal transduction from a variety of cytokines implicated in the pathogenesis of psoriasis, including interleukin (IL)-12, IL-23, and interferon-γ. INCB018424, a small molecule inhibitor of JAK1 and JAK2, inhibits cytokine-induced JAK/signal transducers and activators
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