D9175

Dantrolene sodium salt

Name: Dantrolene sodium salt
Brand: SIGMA

Ca2+ release from sarcoplasmic reticulum inhibitor, solid

Synonym(s):

1-[(5-(p-Nitrophenyl)furfurylidene)amino]hydantoin sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₉N₄NaO₅

CAS Number:

14663-23-1

Molecular Weight:

336.23

UNSPSC Code:

12352200

PubChem Substance ID:

24278823

NACRES:

NA.77

MDL number:

MFCD00079130

Product Name

Dantrolene sodium salt,

SMILES string

[Na+].[H]\C(=N/N1CC(=O)N=C1[O-])c2ccc(o2)-c3ccc(cc3)[N+]([O-])=O

InChI key

KSRLIXGNPXAZHD-HAZZGOGXSA-M

InChI

1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

form

solid

originator

JHP Pharmaceuticals

Quality Level

200

Gene Information

human ... RYR1(6261), RYR3(6263)

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

Inhibitor of Ca²⁺ release from sarcoplasmic reticulum; muscle relaxant.

Features and Benefits

This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by JHP Pharmaceuticals. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000462259

0000453983

0000453984

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Rhynchophylline Regulates Calcium Homeostasis by Antagonizing Ryanodine Receptor 2 Phosphorylation to Improve Diabetic Cardiomyopathy.

Jiao Liu et al.

Frontiers in pharmacology, 13, 882198-882198 (2022-05-07)

Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to heart failure and death, for which there is no effective treatment. Rhynchophylline (Rhy) is the main effective component of the Chinese herbal medicine Uncaria rhynchophylla, which mainly

Calcium channel blockers and dantrolene differentially regulate the production of interleukin-12 and interferon-gamma in endotoxemic mice.

Z H Németh et al.

Brain research bulletin, 46(3), 257-261 (1998-07-17)

Recent studies suggested that transmitters released from the sympathetic nerve terminals can modulate various inflammatory responses by occupation of receptors on immune cells. These neurotransmitters act via alteration of intracellular concentration of second messengers. For instance, intracellular calcium as a

Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?

S K Song et al.

Proceedings of the National Academy of Sciences of the United States of America, 90(9), 3933-3937 (1993-05-01)

Severe bloodstream-borne infection--i.e., sepsis--and the resulting multiorgan failure are now the most common cause of death in many intensive care units. One of the most fundamentally important and controversial issues concerning the pathophysiology of sepsis is the role of intracellular

Pharmacological Comparisons Between Cannabidiol and KLS-13019.

Douglas E Brenneman et al.

Journal of molecular neuroscience : MN, 66(1), 121-134 (2018-08-16)

Cannabidiol (CBD) exhibits neuroprotective properties in many experimental systems. However, development of CBD as a drug has been confounded by the following: (1) low potency; (2) a large number of molecular targets; (3) marginal pharmacokinetic properties; and (4) designation as

Modulation by dantrolene of endotoxin-induced interleukin-10, tumour necrosis factor-alpha and nitric oxide production in vivo and in vitro.

G Haskó et al.

British journal of pharmacology, 124(6), 1099-1106 (1998-08-28)

1. Intracellular calcium has been suggested to be an important mediator of the cellular response in endotoxaemia and shock. Dantrolene is an agent that interferes with intracellular calcium fluxes resulting in a decreased availability of calcium in the cytoplasm. Here

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