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F0881

Fusidic acid sodium salt

Name: Fusidic acid sodium salt
Brand: SIGMA

≥98% (TLC), Bacterial protein synthesis inhibitor

Synonym(s):

Fucidin

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About This Item

Linear Formula:

C₃₁H₄₇O₆Na

CAS Number:

751-94-0

Molecular Weight:

538.69

NACRES:

NA.77

PubChem Substance ID:

24278430

UNSPSC Code:

12352106

EC Number:

212-030-3

MDL number:

MFCD09054714

Assay:

≥98% (TLC)

Quality level:

200

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Properties

Product Name

Fusidic acid sodium salt, ≥98% (TLC)

Quality Level

200

assay

≥98% (TLC)

solubility

H₂O: soluble

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].C[C@@H]1[C@H](O)CC[C@@]2(C)C1CC[C@@]3(C)C2[C@H](O)CC4\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C([O-])=O

InChI

1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1

InChI key

HJHVQCXHVMGZNC-JCJNLNMISA-M

Description

General description

Fusidic acid is an antibiotic substance, resembling the structure of a steroid. It belongs to the class of fusidanes.

Application

Fusidic acid sodium salt has been used to study the effects of three-drug combinations on the growth rate of a bacterium, wild-type Escherichia coli. It is also used to study the in vitro susceptibility of dog-derived European methicillin-resistant Staphylococcus pseudintermedius and Staphylococcus aureus strains and their methicillin-susceptible counterparts.

Biochem/physiol Actions

Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Suppresses nitric oxide lysis of pancreatic islet cells; inhibits protein synthesis in prokaryotes.

Fusidic acid possesses antimicrobial action against skin pathogens. It is highly specific to Staphylococcus aureus. It is therefore used for treating infected traumatic wounds, folliculitis, furunculosis, impetigo, erythrasma and abscesses.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Hazard Classifications

Acute Tox. 4 Oral

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Fusidic acid in dermatology

British Journal of Dermatology, 37-40 (1998)

Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs

<BIG>Tekin E, et al.</BIG>

Journal of the Royal Society, Interface / the Royal Society, 20160332-20160332 (2016)

Susceptibility in vitro of canine methicillin-resistant and-susceptible staphylococcal isolates to fusidic acid, chlorhexidine and miconazole: opportunities for topical therapy of canine superficial pyoderma

<BIG>Clark SM, et al. </BIG>

The Journal of Antimicrobial Chemotherapy, 2048-2052 (2015)

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