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G0759

Sodium glycochenodeoxycholate

Synonym(s):

3α,7α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide sodium salt, Glycochenodeoxycholic acid sodium salt, N-(3α,7α-Dihydroxy-24-oxocholan-24-yl)glycine sodium salt

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About This Item

Empirical Formula (Hill Notation):
C26H42NNaO5
CAS Number:
16564-43-5
Molecular Weight:
471.61
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
24895023
MDL number:
MFCD00036743
Beilstein/REAXYS Number:
3847290
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description

anionic

Quality Level

200

form

powder

mol wt

471.61 g/mol

technique(s)

HPLC: suitable, protein quantification: suitable

functional group

sulfonic acid

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].C[C@H](CCC(=O)NCC([O-])=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/m1./s1

InChI key

AAYACJGHNRIFCT-YRJJIGPTSA-M

General description

Glycochenodeoxycholate (GCDC) is a toxic hydrophobic bile salt.

Application

Sodium glycochenodeoxycholate has been used as an additive in de Man, Rogosa and Sharpe (MRS) agar for bile acid deconjugation to determine the capacity of the strains to deconjugate specific bile acids.
Sodium glycochenodeoxycholate has been used in a study to assess the repair of DNA damage induced by bile salts. It has also been used in a study to investigate enterotoxin production by Clostridium perfringens type A in the presence of human bile salts.

Biochem/physiol Actions

Glycochenodeoxycholate (GCDC) can induce hepatocyte apoptosis that is partially mediated by Fas.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000513849
0000513848
0000528519
0000528519
0000513849

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Lin Lin et al.
American journal of translational research, 11(6), 3365-3374 (2019-07-18)
Human noroviruses (HuNoVs) are a major cause of epidemic and sporadic cases of acute gastroenteritis worldwide. Recently, human intestinal enteroids (HIEs) have been shown to support the replication of HuNoVs, and be an excellent model to study HuNoV-host interactions. We
Robert L Atmar et al.
The Journal of infectious diseases, 221(5), 739-743 (2019-10-16)
The development of an in vitro cultivation system for human noroviruses allows the measurement of neutralizing antibody levels. Serum neutralizing antibody levels were determined using a GII.4/Sydney/2012-like virus in human intestinal enteroids in samples collected before and 4 weeks after
Ana I Prieto et al.
Genetics, 174(2), 575-584 (2006-08-05)
Exposure of Salmonella enterica to sodium cholate, sodium deoxycholate, sodium chenodeoxycholate, sodium glycocholate, sodium taurocholate, or sodium glycochenodeoxycholate induces the SOS response, indicating that the DNA-damaging activity of bile resides in bile salts. Bile increases the frequency of GC -->
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