N2288
Nefiracetam
solid
Synonym(s):
(2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide), DM-9384
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About This Item
Empirical Formula (Hill Notation):
C14H18N2O2
CAS Number:
Molecular Weight:
246.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
color
white to off-white
solubility
DMSO: >5 mg/mL
SMILES string
Cc1cccc(C)c1NC(=O)CN2CCCC2=O
InChI
1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
InChI key
NGHTXZCKLWZPGK-UHFFFAOYSA-N
Biochem/physiol Actions
Nefiracetam (NEF) is a pyrrolidonetype nootropic agent with various pharmacologic as well as cognition enhancing effects. In amygdala-kindled seizures, nefiracetam inhibits both electroencephalographic and behavioral seizures. NEF has a distinct anticonvulsant spectrum.
Novel pyrrolidonetype nootropic (condition enhancing) agent with anticonvulsant spectrum.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Shigeki Moriguchi et al.
Journal of neurochemistry, 106(3), 1092-1103 (2008-05-01)
Nefiracetam is a pyrrolidine-related nootropic drug exhibiting various pharmacological actions such as cognitive-enhancing effect. We previously showed that nefiracetam potentiates NMDA-induced currents in cultured rat cortical neurons. To address questions whether nefiracetam affects NMDA receptor-dependent synaptic plasticity in the hippocampus
Ricardo E Jorge et al.
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 55(6), 350-354 (2010-06-15)
We will review the available evidence on the frequency, clinical correlates, mechanism, and treatment of apathy following stroke. We have explored relevant databases (that is, PubMed, MEDLINE, and PsycINFO) using the following key words and their combinations: apathy, motivation, abulia
Robert G Robinson et al.
The Journal of neuropsychiatry and clinical neurosciences, 20(2), 178-184 (2008-05-03)
In preliminary trials, nefiracetam, a gamma aminobutyric compound, enhanced blood flow and improved mood following stroke. Within 3 months following stroke with major depression, 159 patients were enrolled in a double-blind trial of nefiracetam or placebo. Repeated measures analysis of