O6503
L-Ornithine monohydrochloride
BioReagent, suitable for cell culture, ≥99%
Synonym(s):
(S)-2,5-Diaminopentanoic acid monohydrochloride
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About This Item
Empirical Formula (Hill Notation):
C5H12N2O2 · HCl
CAS Number:
Molecular Weight:
168.62
UNSPSC Code:
12352209
NACRES:
NA.75
PubChem Substance ID:
EC Number:
221-678-6
Beilstein/REAXYS Number:
3625847
MDL number:
Biological source:
microbial
Form:
powder
Technique(s):
cell culture | mammalian: suitable
Assay:
≥99%
biological source
microbial
Quality Level
product line
BioReagent
assay
≥99%
form
powder
packaging
pkg of 100 g, pkg of 25 g
technique(s)
cell culture | mammalian: suitable
impurities
ammonia and citrulline, essentially free
solubility
H2O: soluble 50 mg/mL, clear, colorless to very faintly yellow
SMILES string
Cl.NCCC[C@H](N)C(O)=O
InChI
1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
InChI key
GGTYBZJRPHEQDG-WCCKRBBISA-N
General description
L-Ornithine is the functional metabolite of L-arginine.
L-Ornithine is an amino acid that is not coded for by the genetic code. It is formed during the decomposition of argininine by arginase and participates in the urea cycle. Ornithine is the starting point for the formation of a family of polyamines that include spermine, spermidine and putrescine.
Application
L-Ornithine monohydrochloride has been used:
- as a supplement in Dulbecco′s modified eagle medium (DMEM) for cell growth assays
- as a component in the standard medium for primary human hepatocytes (PHH) culture
- as a creatine synthesis inhibitor
Biochem/physiol Actions
L-ornithine acts as a precursor for polyamines. It may modulate the intake of food as an acute satiety signal in the neonatal chick brain.
L-Ornithine is used as a media supplement to support the biosynthesis of polyamines.
Other Notes
Product of arginine degradation by arginase
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
Ji L, et al.
Immunity, 51(2), 272-284 (2019)
Arginine
Profiles of Drug Substances, Excipients, and Related Methodology, 27, 1-32 (2001)
Z N Canellakis et al.
The Yale journal of biology and medicine, 62(5), 481-491 (1989-09-01)
The polyamines and their derivatives are essential for life in eukaryotic and most prokaryotic cells, but their exact role in preserving cell function is not clear. These polyamines provide endogenous cations and thus participate in regulation of the intracellular pH;