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Merck

PLA0060

Rabbit anti-MCM2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

BM28, CCNL1, CDCL1, D3S3194, DFNA70, KIAA0030, MCM2 minichromosome maintenance deficient 2, cdc19, cell devision cycle-like 1, cyclin-like 1, minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin), minichromosome maintenance deficient 2 (mitotin), minichromosome maintenance protein 2 homolog, mitotin, mitotin (S. cerevisiae), nuclear protein BM28

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, IP, WB
Species reactivity:
human, mouse
Citations:
1
Technique(s):
immunohistochemistry: 1:2,000-1:10,000, immunoprecipitation (IP): 2- 5 μg/mg, western blot: 1:1,000- 1:10,000
Uniprot accession no.:
P49736

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

technique(s)

immunohistochemistry: 1:2,000-1:10,000, immunoprecipitation (IP): 2- 5 μg/mg, western blot: 1:1,000- 1:10,000

accession no.

NP_0045117.2

UniProt accession no.

P49736

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rabbit ... MCM2(4171)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

The epitope recognized by PLA0060 maps to a region between residues 1 and 50 of human human minichromosomal maintenance deficient 2 using the numbering given in entry NP_0045117.2 (GeneID 4171).

Other Notes

The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM2 interacts with the core MCM complex (MCM4, 6, and 7) to regulate its helicase activity.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
2

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Maïté Leturcq et al.
Cellular and molecular life sciences : CMLS, 75(23), 4321-4339 (2018-08-03)
O-GlcNAcylation of proteins is governed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). The homeostasis of O-GlcNAc cycling is regulated during cell cycle progression and is essential for proper cellular division. We previously reported the O-GlcNAcylation of the minichromosome maintenance proteins

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