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R2530

Ropinirole hydrochloride

Name: Ropinirole hydrochloride
Brand: SIGMA

≥98% (HPLC), D2 and D3 dopamine receptor agonist, powder

Sinónimos:

4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride, SKF 101468 hydrochloride

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Fórmula empírica (notación de Hill):

C₁₆H₂₄N₂O · HCl

Número CAS:

91374-20-8

Peso molecular:

296.84

UNSPSC Code:

12352200

PubChem Substance ID:

329824018

NACRES:

NA.77

MDL number:

MFCD01754173

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Propiedades

Nombre del producto

Ropinirole hydrochloride, powder, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

light yellow

solubility

H₂O: >10 mg/mL

originator

GlaxoSmithKline

SMILES string

Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12

InChI

1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H

InChI key

XDXHAEQXIBQUEZ-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815)

Descripción

Biochem/physiol Actions

Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.

An agonist at the D₂ and D₃ dopamine receptor subtypes, binding with higher affinity to D₃ than to D₂ or D₄. It has negligible effect on D₁-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT₁, 5-HT₂, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.

Selective D₂ dopamine receptor agonist, antiparkinsonian

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H400

pcodes

P264 - P270 - P273 - P301 + P312 - P391 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c