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Merck

S1820

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt

≥98% (HPLC), Thrombin receptor activating peptide, lyophilized powder

Synonym(s):

PAR-1 (Protease-Activated Receptor) Selective Activating Peptide, PAR1-AP, SFLLRN-NH2

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About This Item

Linear Formula:
C34H57N11O8 · x CF3COOH
CAS Number:
141923-40-2
Molecular Weight:
747.89 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329824491
NACRES:
NA.32
MDL number:
MFCD18782166

Product Name

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt, ≥98% (HPLC), lyophilized powder

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O

InChI key

YICKZNIVMKPQPD-POCCEKOUSA-N

InChI

1S/C34H57N11O8.C2HF3O2/c1-18(2)13-24(31(51)41-22(11-8-12-40-34(38)39)30(50)42-23(28(37)48)16-27(36)47)44-32(52)25(14-19(3)4)45-33(53)26(43-29(49)21(35)17-46)15-20-9-6-5-7-10-20;3-2(4,5)1(6)7/h5-7,9-10,18-19,21-26,46H,8,11-17,35H2,1-4H3,(H2,36,47)(H2,37,48)(H,41,51)(H,42,50)(H,43,49)(H,44,52)(H,45,53)(H4,38,39,40);(H,6,7)/t21-,22-,23-,24-,25-,26-;/m0./s1

assay

≥98% (HPLC)

form

lyophilized powder

color

white

UniProt accession no.

P08069

storage temp.

−20°C

Quality Level

100

Gene Information

human ... IGF1R(3480)

Related Categories

Application

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt has been used as a protease-activated receptor 1 (PAR-1) selective activating peptide.

Biochem/physiol Actions

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt (SFLLRN) acts as a protease-activated receptor 1 (PAR-1) specific agonist peptide.
Thrombin receptor activating peptide (TRAP).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000417327
0000417327
0000413933
0000413933
0000199197

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J. S. Davies
Amino Acids, Peptides and Proteins, 29 (1998)
Thrombin induces Ca2+-dependent glutamate release from RPE cells mediated by PLC/PKC and reverse Na+/Ca2+ exchange
Lopez E, et al.
Molecular Vision (2019)
Nicola Maggio et al.
Hippocampus, 24(8), 1030-1038 (2014-04-23)
Thrombin and other clotting factors regulate long-term potentiation (LTP) in the hippocampus through the activation of the protease activated receptor 1 (PAR1) and consequent potentiation of N-methyl-d-aspartate receptor (NMDAR) functions. We have recently shown that the activation of PAR1 either
M Rijkers et al.
Vox sanguinis, 111(3), 247-256 (2016-10-22)
In mice, loss of sialic acid resulting in shedding of glycoprotein (GP) Ibα and GPV has been linked to platelet survival. The aim of this study was to determine whether loss of sialic acid and the GPIb-IX-V complex contributes to
Visualizing dynamics of cell signaling in vivo with a phase separation-based kinase reporter
Zhang Q, et al.
Molecular Cell, 69(2), 334-346 (2018)
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