U6625

Uridine 5′-triphosphate trisodium salt hydrate

Name: Uridine 5′-triphosphate trisodium salt hydrate
Brand: SIGMA

From yeast, ≥96%, P2Y receptor agonist

Synonym(s):

UTP Na₃

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₂N₂Na₃O₁₅P₃ · xH₂O

CAS Number:

19817-92-6

Molecular Weight:

550.09 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24900436

UNSPSC Code:

12352200

MDL number:

MFCD00044310

Beilstein/REAXYS Number:

3585234

Product Name

Uridine 5′-triphosphate trisodium salt hydrate, from yeast, Type III, ≥96%

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

biological source

yeast

type

Type III

assay

≥96%

solubility

H₂O: soluble 50 mg/mL, clear to slightly hazy, colorless

Quality Level

200

shipped in

dry ice

storage temp.

−20°C

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Related Categories

Bioactive Small Molecule Agonists

Bioactive Small Molecules

Phosphates

Application

UTP has been used to study its vasodilatory effects on the skeletal muscle cells of diabetic patients. UTP has also been used as a purinergic agonist to study ion transport functions of P2Y2 receptors on rat basolateral membranes.

Biochem/physiol Actions

P2Y receptor agonist.

Preparation Note

Uridine 5′-triphosphate trisodium salt (UTP Na₃) hydrate dissolves in water at 50 mg/ml to yield a clear to slightly hazy, colorless solution.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3-kinase within the semicircular canal duct epithelium.

Satyanarayana R Pondugula et al.

BMC research notes, 3, 100-100 (2010-04-20)

The ionic composition of the luminal fluid in the vestibular labyrinth is maintained within tight limits by the many types of epithelial cells bounding the lumen. Regulatory mechanisms include systemic, paracrine and autocrine hormones along with their associated intracellular signal

A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1.

Xiping Chen et al.

FEBS letters, 595(1), 110-122 (2020-10-25)

O-GlcNAcylation is a post-translational modification catalysed by O-GlcNAc transferase (OGT). Missense mutations in OGT have been associated with developmental disorders, OGT-linked congenital disorder of glycosylation (OGT-CDG), which are characterized by intellectual disability. OGT relies on the hexosamine biosynthetic pathway (HBP)

Dielectric spectra broadening as a signature for dipole-matrix interaction. III. Water in adenosine monophosphate/adenosine-5'-triphosphate solutions.

Alexander Puzenko et al.

The Journal of chemical physics, 137(19), 194502-194502 (2012-11-28)

In this, the third part of our series on the dielectric spectrum symmetrical broadening of water, we consider the nucleotide aqueous solutions. Where in Parts I [E. Levy et al., J. Chem. Phys. 136, 114502 (2012)] and II [E. Levy

The YdiU Domain Modulates Bacterial Stress Signaling through Mn2+-Dependent UMPylation.

Yinlong Yang et al.

Cell reports, 32(12), 108161-108161 (2020-09-24)

Sensing stressful conditions and adjusting the cellular metabolism to adapt to the environment are essential activities for bacteria to survive in variable situations. Here, we describe a stress-related protein, YdiU, and characterize YdiU as an enzyme that catalyzes the covalent

Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference.

Lilan You et al.

Cell, 176(1-2), 239-253 (2018-12-07)

Csm, a type III-A CRISPR-Cas interference complex, is a CRISPR RNA (crRNA)-guided RNase that also possesses target RNA-dependent DNase and cyclic oligoadenylate (cOA) synthetase activities. However, the structural features allowing target RNA-binding-dependent activation of DNA cleavage and cOA generation remain

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