W108
WAY-100635 maleate salt
5-HT1A serotonin receptor antagonist, powder
Synonym(s):
N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate salt
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About This Item
Empirical Formula (Hill Notation):
C25H34N4O2 · C4H4O4
CAS Number:
Molecular Weight:
538.64
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
Quality level:
Product Name
WAY-100635 maleate salt, powder
form
powder
Quality Level
color
white
solubility
H2O: 25 mg/mL
SMILES string
[H]\C(=C(/[H])C(O)=O)C(O)=O.COc1ccccc1N2CCN(CC2)CCN(C(=O)C3CCCCC3)c4ccccn4
InChI
1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
XIGAHNVCEFUYOV-BTJKTKAUSA-N
Gene Information
human ... HTR1A(3350)
Application
WAY-100635 maleate salt has been used as a 5-HT1A serotonin receptor antagonist:
- to study whether the behavior of the cleaner wrasse is regulated by serotonin activity
- to block activity of 3,4 methylenedioxymethamphetamine (MDMA) used to induce oxytocin release in male Wistar rats to increase their social behavior
- to study the role of serotonin during metamorphosis of the ascidian Phallusia mammillata larvae
Biochem/physiol Actions
WAY-100635 maleate salt is a highly selective 5-HT1A serotonin receptor antagonist. It has an ability to inhibit brexpiprazole, an antipsychotic drug that regulates serotonin-dopamine activity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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H Gozlan et al.
European journal of pharmacology, 288(2), 173-186 (1995-01-16)
The tritiated derivative of the novel silent 5-HT1A receptor antagonist WAY 100635 [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane carboxamide] was tested as a potential radioligand of 5-HT1A receptors in the rat brain. Binding assays with membranes from various brain regions showed that [3H]WAY 100635
Mehdi Sekssaoui et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 49(4), 747-756 (2024-01-12)
Major depressive disorder (MDD) is one of the most disabling psychiatric disorders in the world. First-line treatments such as selective serotonin reuptake inhibitors (SSRIs) still have many limitations, including a resistance to treatment in 30% of patients and a delayed
Naozumi Araragi et al.
Frontiers in pharmacology, 4, 97-97 (2013-08-13)
Firing activity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) is controlled by inhibitory somatodendritic 5-HT1A autoreceptors. This autoinhibitory mechanism is implicated in the etiology of disorders of emotion regulation, such as anxiety disorders and depression, as well