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Merck

1098130

USP

Ceftazidime pentahydrate

United States Pharmacopeia (USP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C22H22N6O7S2 · 5H2O
CAS Number:
78439-06-2
Molecular Weight:
636.65
MDL number:
MFCD32695622
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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Product Name

Ceftazidime pentahydrate, United States Pharmacopeia (USP) Reference Standard

SMILES string

[s]1c(nc(c1)\C(=N\OC(C)(C)C(=O)[O-])\C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)[O-])C[n+]4ccccc4)N.O.O.O.O.O.[H+]

InChI

1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1...../s1

InChI key

NMVPEQXCMGEDNH-TZVUEUGBSA-N

grade

pharmaceutical primary standard

API family

ceftazidime

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Ceftazidime pentahydrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Ceftazidime
  • Ceftazidime Injection
  • Ceftazidime for Injection

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Ceftazidime
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(3), 872-872 (2018)
M A Sirgo et al.
DICP : the annals of pharmacotherapy, 25(3), 284-288 (1991-03-01)
The disposition of drugs in the elderly is particularly relevant with antiinfectives, because this population has an increased risk of infections. Renal function deteriorates with age, yet dosage guidelines for antibiotics that allow for this reduction remain to be established.
A Walkty et al.
Antimicrobial agents and chemotherapy, 57(11), 5707-5709 (2013-08-14)
The in vitro activity of ceftolozane in combination with tazobactam (fixed concentration of 4 μg/ml) was evaluated against 2,435 Pseudomonas aeruginosa clinical isolates obtained from across Canada using Clinical and Laboratory Standards Institute broth microdilution methods. The MIC50 and MIC90
Francisco José Pérez-Llarena et al.
Antimicrobial agents and chemotherapy, 57(10), 5158-5161 (2013-07-24)
A novel class C β-lactamase (FOX-8) was isolated from a clinical strain of Escherichia coli. The FOX-8 enzyme possessed a unique substitution (Phe313Leu) compared to FOX-3. Isogenic E. coli strains carrying FOX-8 showed an 8-fold reduction in resistance to ceftazidime
George G Zhanel et al.
Drugs, 73(2), 159-177 (2013-02-02)
Avibactam (formerly NXL104, AVE1330A) is a synthetic non-β-lactam, β-lactamase inhibitor that inhibits the activities of Ambler class A and C β-lactamases and some Ambler class D enzymes. This review summarizes the existing data published for ceftazidime-avibactam, including relevant chemistry, mechanisms
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