69400
6-Methyl-2-thiouracil
purum, ≥98.0% S basis (elemental analysis)
Synonym(s):
Basethyrin, Methiocil, Thiothymin, 4-Hydroxy-2-mercapto 6-methylpyrimidine, MZU
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About This Item
Empirical Formula (Hill Notation):
C5H6N2OS
CAS Number:
Molecular Weight:
142.18
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-252-3
Beilstein/REAXYS Number:
115648
MDL number:
Assay:
≥98.0% S basis (elemental analysis)
Form:
crystals
grade
purum
Quality Level
assay
≥98.0% S basis (elemental analysis)
form
crystals
mp
~330 °C (dec.) (lit.)
SMILES string
CC1=CC(=O)NC(=S)N1
InChI
1S/C5H6N2OS/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9)
InChI key
HWGBHCRJGXAGEU-UHFFFAOYSA-N
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General description
6-Methyl-2-thiouracil possesses antithyroid activity.
Application
6-Methyl-2-thiouracil can be used in:
- Synthesis of luminescent gold(I) thiouracilate complexes as emissive materials.
- Synthesis of uracil-containing histone deacetylase inhibitors.
- Synthesis of S-dihydro-alkylthio-benzyl-oxopyrimidines (S-DABOs) based anti-HIV agents.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
Mai A, et al.
Journal of Medicinal Chemistry, 49(20), 6046-6056 (2006)
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors.
Mugnaini C, et al.
Bioorganic & Medicinal Chemistry Letters, 16(13), 3541-3544 (2006)
Antithyroid Drugs and their Analogues Protect Against Peroxynitrite-Mediated Protein Tyrosine Nitration-A Mechanistic Study.
Bhabak KP and Mugesh G
Chemistry?A European Journal , 16(4), 1175-1185 (2010)
D Matthias et al.
Atherosclerosis, 122(2), 201-216 (1996-05-01)
Following oral administration of methionine in high doses to normotensive (NR) and spontaneously hypertensive (SHR) rats, its degradation product, homocysteine (HC), which is markedly elevated in serum, exerts an angiotoxic action directed to the aorta. This is accompanied by considerable
P Batjoens et al.
Journal of chromatography. A, 750(1-2), 127-132 (1996-10-25)
A more sensitive method was developed using the hyphenated technique of gas chromatography-mass spectrometry (GC-MS) supplementary to the official high-performance thin-layer chromatography (HPTLC) method. Even combined with less efficient extraction and clean-up methods, GC-MS is able to lower the detection
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