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Merck

P1800000

Pindolol

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

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About This Item

Empirical Formula (Hill Notation):
C14H20N2O2
CAS Number:
13523-86-9
Molecular Weight:
248.32
NACRES:
NA.24
PubChem Substance ID:
329820108
UNSPSC Code:
41116107
MDL number:
MFCD00010530

Key Documents

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Product Name

Pindolol, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

SMILES string

CC(C)NCC(O)COc1cccc2[nH]ccc12

InChI key

JZQKKSLKJUAGIC-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

pindolol

manufacturer/tradename

EDQM

mp

167-171 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... ADRB1(153), ADRB2(154)

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Related Categories

Application

Pindolol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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J S Olver et al.
The Australian and New Zealand journal of psychiatry, 34(1), 71-79 (2001-02-24)
To critically review the literature on clinical trials in which pindolol, a 5HT1A receptor antagonist, has been used to augment the effects of antidepressants in patients with depression and to examine the pharmacodynamics and pharmacokinetics that may underlie such augmentations.
Antihypertensive effects of pindolol.
L M Gonasun
American heart journal, 104(2 Pt 2), 374-387 (1982-08-01)
D Herpin et al.
Annales de medecine interne, 139(7), 484-487 (1988-01-01)
Twenty-one patients with mild or moderate hypertension were randomised to receive either Atenolol 100 mg (N = 10) or Pindolol 15 mg (N = 11) in a once daily dosage over a two month period. The effects of these two
H Duner
British journal of clinical pharmacology, 24 Suppl 1, 51S-54S (1987-01-01)
1. In recent years evidence has accumulated which indicates that although various beta-adrenoceptor antagonists are equally effective in lowering blood pressure in patients with essential hypertension the mechanisms of action of the different drugs are heterogeneous. 2. Pindolol, a beta-adrenoceptor
R McAskill et al.
The British journal of psychiatry : the journal of mental science, 173, 203-208 (1999-02-02)
Antidepressant therapy is not always effective and is slow to take effect. In theory, these shortfalls may be caused by induction of neuronal negative feedback via pre-synaptic 5-HTIA receptors. Pindolol, an antagonist at somatodentritic pre-synaptic 5-HTIA receptors has been investigated
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