79470
D(+)-2-Phosphoglyceric acid sodium salt hydrate
≥75% (calc. on dry substance, enzymatic)
Synonym(s):
D-Glycerate 2-phosphate sodium salt, Sodium D-2-phosphoglycerate hydrate
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About This Item
Empirical Formula (Hill Notation):
C3H7O7P · xNa+ · yH2O
CAS Number:
Molecular Weight:
186.06 (anhydrous free acid basis)
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.26
Assay:
≥75% (calc. on dry substance, enzymatic)
Form:
powder
Quality Level
assay
≥75% (calc. on dry substance, enzymatic)
form
powder
impurities
≤1% Pi, ≤35% water
storage temp.
−20°C
SMILES string
O=C(O)[C@@H](CO)OP(O)(O)=O.C.C
InChI key
PXJAQZYAJDMQJH-YBBRRFGFSA-N
Biochem/physiol Actions
Enantiomerically pure metabolite of glycolysis/gluconeogenesis and also substrate for a number of important enzymes in central metabolism like enolase and phosphoglycerate mutase.
The enzyme enolase is responsible for reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). Phosphoglycerate mutase causes reversible isomerization of 3-phosphoglycerate and 2-phosphoglycerate in glycolysis and gluconeogenesis.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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T M Larsen et al.
Biochemistry, 35(14), 4349-4358 (1996-04-09)
The equilibrium mixture of yeast enolase with substrate, 2-phospho-D-glycerate (2-PGA), and product, phosphoenolpyruvate (P-enolpyruvate), has been crystallized from solutions of poly(ethylene glycol) (PEG) at pH 8.0. Crystals belong to the space group C2 and have unit cell dimensions a =
Shivangi Agarwal et al.
Biochimica et biophysica acta, 1784(7-8), 986-994 (2008-05-06)
alpha-enolase of Bacillus anthracis has recently been classified as an immunodominant antigen and a potent virulence factor determinant. alpha-enolase (2-phospho-d-glycerate hydrolase (EC 4.2.1.11), a key glycolytic metalloenzyme catalyzes the dehydration of d-(+)-2-phosphoglyceric acid to phosphoenolpyruvate. Interaction of surface bound alpha-enolase
Molecular characterization of phosphoglycerate mutase in archaea.
van der Oost J, et al.
FEMS Microbiology Letters, 212, 111-120 (2002)