A6060
Calpain Inhibitor II
powder
Synonym(s):
N-Acetyl-L-leucyl-L-leucyl-L-methioninal
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About This Item
Empirical Formula (Hill Notation):
C19H35N3O4S
CAS Number:
Molecular Weight:
401.56
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
7693643
InChI
1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
SMILES string
[H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
InChI key
RJWLAIMXRBDUMH-ULQDDVLXSA-N
assay
≥95% (HPLC)
form
powder
color
white
solubility
ethanol: 20 mg/mL
storage temp.
−20°C
Quality Level
Related Categories
Application
Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.
Biochem/physiol Actions
Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.
Other Notes
Formerly CAS# 136632-32-1
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Keduo Qian et al.
Bioorganic & medicinal chemistry letters, 21(19), 5944-5947 (2011-08-23)
In this study, 22 new betulinic acid (BA) derivatives were synthesized and tested for their inhibition of the chymotrypsin-like activity of 20S proteasome. From the SAR study, we concluded that the C-3 and C-30 positions are the pharmacophores for increasing
Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels
Ziyatdinova S, et al.
Epilepsy Research (2011)
The cyclin-dependent kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4
Al Sorkhy M, et al.
The Journal of Biological Chemistry, 284(5), 2617-2627 (2009)
Aneurysm: New Insights for the Healthcare Professional, 56-57 (2013)
J Sebastián Yakisich et al.
Investigational new drugs, 28(3), 242-250 (2009-03-17)
By using mini-units of tissue and protease inhibitors in short term incubation (0-180 min), we studied the role of proteolysis for ongoing DNA replication in the developing rat cerebral cortex. The protease inhibitors TLCK, TPCK, PMSF, MG-132 and PSI markedly
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