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Merck

A6553

DL-2-Amino-5-phosphonovaleric acid lithium salt

~95%

Synonym(s):

DL-2-Amino-5-phosphonopentanoic acid, AP-5

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About This Item

Linear Formula:
C5H11NO5PLi
CAS Number:
125229-62-1
Molecular Weight:
203.06
NACRES:
NA.26
PubChem Substance ID:
24891104
UNSPSC Code:
12352106
MDL number:
MFCD00078901

Key Documents

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Product Name

DL-2-Amino-5-phosphonovaleric acid lithium salt, ~95%

InChI

1S/C5H12NO5P.Li.H/c6-4(5(7)8)2-1-3-12(9,10)11;;/h4H,1-3,6H2,(H,7,8)(H2,9,10,11);;

SMILES string

[Li].NC(CCCP(O)(O)=O)C(O)=O

InChI key

QIVHTKSFMZBERS-UHFFFAOYSA-N

assay

~95%

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

Quality Level

100

Gene Information

rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)

Related Categories

Biochem/physiol Actions

Anticonvulsant; potent and selective antagonist for NMDA receptors.
DL-2-Amino-5-phosphonovaleric acid is a selective N-methyl-d-aspartate (NMDA) receptor antagonist used frequently in studies of neurological processes

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000227048
0000227048
0000142631
0000136619
0000074443

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Guan Cao et al.
Journal of neurophysiology, 107(3), 902-912 (2011-11-25)
Long-term potentiation (LTP) is a form of synaptic plasticity thought to underlie memory; thus knowing its developmental profile is fundamental to understanding function. Like memory, LTP has multiple phases with distinct timing and mechanisms. The late phase of LTP (L-LTP)
Jessica M André et al.
Neuropharmacology, 60(4), 617-625 (2010-12-21)
NMDA glutamate receptors (NMDARs) and nicotinic acetylcholine receptors (nAChRs) are both involved in learning and synaptic plasticity. Increasing evidence suggests processes mediated by these receptors may interact to modulate learning; however, little is known about the neural substrates involved in
A Osorio-Espinoza et al.
Neuroscience, 176, 20-31 (2011-01-05)
The globus pallidus, a neuronal nucleus involved in the control of motor behavior, expresses high levels of histamine H(3) receptors (H(3)Rs) most likely located on the synaptic afferents to the nucleus. In this work we studied the effect of the
Thomas K Fung et al.
Synapse (New York, N.Y.), 65(7), 677-686 (2010-12-31)
Synaptic plasticity may depend not only on the afferent fibers but also on the recipient structure. The medial perforant path (MPP) from the entorhinalcortex projects to both the dentate gyrus (DG) and CA3, resulting in excitatory postsynaptic potentials (EPSPs) in
Brandon S Martin et al.
Journal of neurophysiology, 112(4), 890-902 (2014-05-23)
Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability. Comorbidities of FXS such as autism are increasingly linked to imbalances in excitation and inhibition (E/I) as well as dysfunction in GABAergic transmission in a number of brain
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