C8895
Clofazimine
≥98% (TLC), powder, antimycobacterial rimonphenazine
Synonym(s):
N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C27H22Cl2N4
CAS Number:
Molecular Weight:
473.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
217-980-2
MDL number:
Form:
powder
Quality level:
Product Name
Clofazimine,
form
powder
Quality Level
antibiotic activity spectrum
mycobacteria
mode of action
protein synthesis | interferes
originator
Novartis
SMILES string
CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
InChI
1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
InChI key
WDQPAMHFFCXSNU-BGABXYSRSA-N
General description
Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.
Application
Clofazimine has been used:
- for antimicrobial preparation
- to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
- to model drug-induced hepatic granulomatous inflammation
- to study the in vivo cargo storage capacity of macrophages
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
This product is stored at room temperature.
Still not finding the right product?
Explore all of our products under Clofazimine
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
In vitro approaches for generation of Mycobacterium tuberculosis mutants resistant to bedaquiline, clofazimine or linezolid and identification of associated genetic variants
Ismail N, et al.
Journal of Microbiological Methods, 153(8), 1-9 (2018)
Plumb's Veterinary Drug Handbook (2008)
An Expandable Mechanopharmaceutical Device (1): Measuring the Cargo Capacity of Macrophages in a Living Organism
Rzeczycki P, et al.
Pharmaceutical Research, 36(1), 12-12 (2019)